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FARKLI YAŞ GRUBUNDAKİ HASTALARDA PROPOFOL-AZOT PROTOKSİT UYGULAMASININ KAN BASINCI VE KALP HIZI ÜZERİNE OLAN ETKİLERİNİN DEĞERLENDİRİLMESİ

The evaluation of the effects of propofol-N20 anaesthesia on blood pressure and heart rats in different ages

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
In this study, we aimed to evaluate the changes in blood pressure and heart rate in geriatric patients, whose response to the catecholamine release were insufficient as according stress factors, by applying anaesthesia with propofoi-N20-fentanyl combination. Group I involved 11 cases(18-65 years) and Group II involved 13 cases(65-87years). 3 mgAff fentanyl, 0.25 mg/kg dehydrobenzperidol (DHB), 1.5 mg/kg propofol and 0.1 mg/kg vecuronium were used for induction. Maintenance of the anaesthesia was provided with propofol infusion 3.5 mg/kg/h and 50% N20-02 inhalation. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure (MAP) and heart rates (HP) were measured before induction, after induction and 1, 3, 5, 10 and 30 minutes after intubation. The recovery periods of the cases were recorded. SBP, DBP and MAP values of Group I were found decreased a fter induction. These values were remained all through the anaesthesia in Group II. HP was found decreased significantly at 1Û" and 30th minutes of anaesthesia In both groups (p<0.01). HP was found decreased in Group II when compared with Group I preinductionally and a fter induction (p<0.05). The other values of BP and HP in both groups were not changed. Recovery periods of Group II were longer than Group I (p<0.01). We concluded that propofol-N20 anaesthesia caused more decrease in BP and HP in geriatric patients when compared with other adults, however this method may be accepted as an alternative technique because they didn't need any extra therapy for hypotension or bradycardia.
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Abstract (Original Language): 
Bu çalışmada, stres faktör/eriyle salgılanan katekolaminlere cevap verebilme yeteneği zayıflayan geriatrik hastalara, propofol-fentanil N20 uygulanarak, kan basıncı ve kalp hızı değişikliklerinin ortaya konması amaçlanmıştır. Çalışmamızda Grup I (11 olgu) 18-65 yaş arasında, Grup II (13 olgu) 65-87 yaş arasında yer alıyordu. Premedikasyon uygulanmayan olgulara indüksiyonda 3yg/kg fentanil, 0.25 mg/kg dehidrobenzperidol(DHB), 1.5 mg/kg propofol ve 0.1 mg/kg vekuronyum bromür uygulandı. Anestezi idamesi 3.5 mg/kg/saat propofol infüzyonu ve %50 N20- 02 ile sağlandı. Olguların sistolik arter basıncı(SAB), diastolik arter basıncı(DAB), ortalama arter basıncı(OAB) ve kalp atım hızları(KAH), indüksiyondan önce (İÖ), indüksiyondan sonra (İS) ve entübasyondan sonraki (ES) 1,3,5,10 ve 30. dakikalarda ölçüldü. Operasyon bitiminde uyanma süreleri kaydedildi. SAB, DAB ve OAB Grup I'de sadece indüksiyondan sonraki ölçümde düşük bulundu, Grup Il'de anestezi süresince düşük seyretti (p<0.01). KAH; her iki grupta 10. ve 30. dk.da azaldı (p<0.01). Gruplar karşılaştırıldığında; KAH, Grup Il'de Grup I'ye göre indüksiyondan önce ve hemen sonraki ölçümde düşük bulundu (p<0.05). KB ve KAH'nın diğer ölçümleri gruplar arasında farklılık göstermedi (p>0.05). Uyanma süresi, Grup Il'de Grup I'ye göre uzundu (p<0.01). Sonuç olarak, propofol 3.5 mg/kg ile in füzyon uygulamasının geriatrik olgularda indüksiyon öncesine göre erişkinlerden daha fazla kan basıncı ve KAH azalmasına neden olduğu, ancak tedavi gerektirecek bir hipotansiyon ya da bradikardiye neden olmadığı için alternatif bir yön tem olarak kullanılabileceği kanısına varıldı.
FULL TEXT (PDF): 
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  • 4
242-246
  • Turkish

REFERENCES

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