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ADEZYON OLUŞUMUNUN ÖNLENMESİNDE İNTRAPERİTONAL FLAVONOİD (DAFLON 500 mg) TEDAVİSİNİN ROLÜ

Prevention of adhesion formation with intraperitoneal administration of purified micronized flavonoid (daflon 500 mg)

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Objective : To investigate the effect of Daflon 500 mg in the prevention of postoperat ve adhes ons. Design : Forty-two rats underwent unilateral surgical injury to the uterine horn and the parietal peritoneum. The rats were randomly assigned to receive no treatment (control), oral-Daflon 500 mg (Daflon-O), or intraperitoneal-Daflon 500 mg (Daflon-IP). To evaluate the effect veness of flavono d solut on, 5 mL was njected ntraper toneally to the th rd group before abdom nal closure. Sal ne solut on was nst lled ntraper toneally to the other groups at the end of laparotomy. The drug was g ven orally n suspens on to the rats of Daflon-O group. Fourteen days after surgery, a second laparotomy was performed and the adhes on score was determined. The data were analysed by Mann Whitney 8 test. Results : The tenac ty of adhes ons and the mean adhes on score of the Daflon-IP group were significantly lower than the control group ( p?0.005 and p?0.01, respectively). However, there was no signifcant difference in adhesion scores between control and Daflon-O groups ( p>0.05). Conclusion : This study suggests that solution of flavonoid (Daflon 500 mg) adm n stered ntraper toneally reduced adhes on development n th s rat model.
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Abstract (Original Language): 
Amaç : Postoperatif adezyon oluşumunun önlenmesinde flavonoid kullanımının Dr. Ayşe KAFKASLI -- etkisinin araştırılması Materyal ve Metod : Wistar-Albino cinsi 42 ratta cerrahi müdahale ile tek taraflı uterin horn ve pariyetal periton defekti oluşturuldu. Sıçanlar rastgele üç gruba ayrıldı. Birinci gruba standart cerrahi girişimi takiben intraperitonal flavonoid (Daflon-İP; 5 mg/ml aktif maddeden 5 ml) uygulanırken diğer iki gruba serum fizyolojik uygulandı. Bu iki grupdan birine 14 gün süreyle oral flavonoid (Daflon-O; 50mg/kg, günde iki kez) tedavisi verildi. Son grup ise kontrol grubunu oluşturdu. İki hafta sonra adezyon skorlarını tesb t etmek amacıyla tüm ratlar relaparotom ye alındı. İstatistik değerlendirmede Kruskal-Wallis ve Mann Whitney 8 test kullanıldı. Sonuçlar : Daflon-İP grubunda ortalama adezyon skoru ve adezyon direnci kontrol grubuna göre anlamlı derecede düşük bulundu (Sırasıyla p? 0.01 ve p? 0.005). Oral flavono d tedav s uygulanan grup le kontrol grubu arasında adezyon skorları arasında anlamlı farklılık tesbit edilmedi (p>0.05). Tartışma : Çalışma sonuçlarımıza göre cerrahi sonunda uygulanan intraperitonal flavono d tedav s adezyon oluşumunu azaltmakta etk l b r yöntemd r.
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REFERENCES

References: 

I. Gutmann J, Penzias AS, Diamond MP. Adhesions in reproductive surgery. In: Wallach EE, Zacur HA, ed(s). Reproductive Medicine and Surgery. St.Louis, Missouri: Mosby 1995; 681-93.
5. Operative Laparoscopy Study Group. Postoperative adhesion development after operative laparoscopy: evaluation at early second-look procedures. Fertil Steril 1991; 55: 700-4.
3. Stout AL, Steege JF, Dodson WC, Hughes CL. Relationship of laparoscopic findings to self-report of pelvic pain. Am J Obstet Gynecol 1991; 145: 73¬9.
4. Trimbos-Kemper TCM, Trimbos JB, van Hall EV. Adhesion formation after tubal surgery: results of the eight-day laparoscopy in 188 patients. Fertil
Steril 1985; 43: 396-400.
5. Becker JM, Dayton TM, Fazio VW, Beck DE, et al.Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: A prospective, randomised, double-blind multicenter study. J Am Coll Surg 1996; 183: 597-306.
6. Şahin Y, Sağlam A. Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model. Acta Obstet Gynecol Scand 1994; 73: 70-3.
7.
Alata
ş E, Günal Ö. Ratlarda oluşturulan periton defekti modelinde gelişen adezyonların hyaluronat-karboksimetilsellüloz içerikli membran kullanımı ile azaltılması. Türk Fertilite dergisi 1999; 7 (basımda).
8. Whawell SA, Vipond MN, Scott-Coombes DM, Thompson JN. Plasminogen activator inhibitor 5 reduces peritoneal fibrinolytic activity in inflammation.
Br J Surg 1993; 80: 107-9.
9. LeGrand EK, Rodgers KE, Gırgıs W, Struck K, et al. Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models. J Surg Res 1994;
56: 67-71.
10.
Alata
ş E. Postoperatif adezyon oluşumunun önlenmesinde octreotide kullanımının rolü. Jinekoloji ve Obstetrik dergisi 1999; 15:544-6.
II. Bateman BG, Nunley WC, Kitchin JD. Prevention of postoperative peritoneal adhesions with ibuprofen. Fertil Steril 1985; 38: 107-8.
15. diZerega GS. Contemporary adhesion prevention. Fertil Steril 1994; 61:
519-35.
13. Bouskela E, Donyo KA, Verbeuren TJ. Effects of Daflon 500 mg on increased microvascular permeability in normal hamsters. Int J Microcirc
Clin Exp 1995; 15: 55-6.
14. Friesenecker B, Tsai AG, Allegra C, Intaglietta M. Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: in vivo observations in the hamster skin fold. Int J Microcirc Clin Exp 1994; 14: 50-5.
15. Jean T. Mediators involved in inflammation: effects of Daflon 500 mg on their release. Angiology 1994; 45: 554-9.
16. Friesenecker B, Tsai AG, Intaglietta M. Cellular basis of inflammation , edema and the activivty of Daflon 500. Int J Microcirc Clin Exp 1995; 15:
17-51.
17. Linsky CB, Diamond MP, Cunningham T, Constantine B, et al. Adhesion reduction in a rabbit uterine horn model using an absorbable barrier, TC-
7. J Reprod Med 1987; 35: 17-50.
18. Rodgers K, Cohn D, Hotovely A, Pines E, et al. Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models. Fertil Steril 1998;
69: 403-819. Bakkum EA, vanBlitterswijk CA, Dalmeijer RAJ,Trimbos JB. A semiquantitative rat model for intraperitoneal post-operative adhesion formation. Gynecol Obstet Invest 1994; 37: 99-105.
50. Rice VM, Shanti A, Moghissi KS, Leach RE. A comparative evaluation of poloxamer 407 and oxidized regenerated cellulose (Interceed TC7) to reduce postoperative adhesion formation in the rat uterine horn model. Fertil Steril 1993; 59: 901-6.
51. Cypriani B, Limasset B, Carrie ML, LeDoucen C, et al. Antioxidant activity of micronised diosmin on oxygen species from stimulated neutrophils. Biochem Pharmacol 1993; 45: 1531-5.
55. Holtz G. Failure of a nonsteroid anti-inflammatory agent (ibuprofen) to inhibit peritoneal adhesion reformation after lysis. Fertil Steril 1985; 37:
585-3.

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