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KONJESTİF KALP YETMEZLİĞİ OLAN HASTALARDA FONKSİYONEL KARDİYAK STATÜSÜN KALP HIZI DEĞİŞKENLİĞİ ÜZERİNE ETKİSİ

The Effect of Functional Cardiac Status on Heart Rate Variability in Patients with Congestive Heart Failure

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Aims: The dysfunction of cardiac autonomic nervous system has been observed in patients with cardiac fallure. A relation between the depression of heart rate veriabiiity (HRV) and the extent of left ventricular dysfunction has been controversially reported. HRV is used to assess cardiac autonomic function. In this study, we examined HRV parameters and autonomous state in patients with idiopathic dllated cardiomyopathy (DCMP) or congestive heart fallure (CHF). Methods: Cardiac autonomous activity was assessed noninvasively from 24-hour electrocardiographic ambulatory recording by calculating heart rate variability (HRV). Mean RR, SNDD, rMSSD and PNN 50 % were measured in a// patients and contro/ subjects (CS) (18 idiopathic dllated cardiomyopathy patients and 20 control subjects). In addition 18, patients with DCMP or CHF were classified according to functiona/ cardiac status (New York Heart Association). Results: No differences were found between DCMP and CS according to age and sex. Depression of HRV was observed in DCMP patients (Mean RR: 632J83ms vs 727J75ms, P<0.001; SDNN: 83.40J42.25ms vs 138.28J40.13ms, P<0.001; rMSSD: 13.70J5.46ms vs 30.37J18.73ms, P<0.001; PNN 50 /: 1.78J4.34 vs 4.40J5.28, P<0.001). As the degree of functional cardiac class increased, there was a tendency for all HRV parameters to decrease, but these differences were not statistically significant (P=NS). Conclusions: Our data showed that there was a decrease of in a// HRV para metres in DCMP and that the reduced HRV parameters were related to functiona/ cardiac status.
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Abstract (Original Language): 
Amaç: Karddiyak otonom/k sinir sisteminin disfonksyyonu kalp yetersizi/ğ/ olan hastalarda gözlenmektedir. Fakat kalp hızı değişkeniiğindeki (KHD) azalma lle sol ventrikü/ disfonksi-yonun boyutu arasındaki iiişki halen tartışmalıdır. KHD kardiyak otonomik fonksiyonları değerlendirmede kullanılmaktadır. Bu çahşmada idiyopatik dllate kardiyomiyopati (DKMP) veya konjestif kalp yetmeziiği (KKY) olan hastalarda KHD parametrelerini ve otonomik aktivite durumunu araştırdık. Metod: Kardiyak otonomik aktivite KHD hesaplanarak 24 saattik holter kayıtlarından non-invaziv olarak değerlendir/ldi. Ortalama RR, SSND, rMSSD, ve PNN 50 % tüm hastalarda ve kontrol grubunda ölçüldü (18 idiyopatik DKMP ve 20 kontrol grubu). Ayrıca, DKMP veya KKY olan 18 hasta fonksiyonel kardiyak statüslerine göre sınıfandırlldı (New York Kalp Cemiyetinin sınıflandırlmasına göre). Bulgular: DKMP ve kontrol grubu arasında yaş ve cinsiyete göre farklıhk yoktu. KHD'nin baskllanması DKMP hastalarında gözlendi (Ortalama RR: 632±83ms'e karşın 727±75ms, P<0.001; SDNN: 83.40J42.25ms'e karşın 138.28J40.13ms, P<0.001; rMSSD: 13.70±5.46ms'e karşın 30.37J18.73ms, P<0.001; PNN 50 /: 1.78J4.34'e karşın 4.40J5.28, P<0.001). Fonksiyonel kardiyak klas derecesi artıkça, tüm KHD parametrelerinin azalmaya eğiiimi vardı, fakat bu farklıhk istatistikse/ açıdan anlamh değlldi (P=AD). Sonuç: Verilerimiz DKMP de tüm KHD parametrelerinde azalma olduğunu ve azalmış KHD parametrelerinin fonksiyonel kardiyak status lle /lşkkii olduğunu göstermektedir.
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  • 4
321-324
  • Turkish

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