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SPİNAL ANESTEZİ İLE SEZARYEN UYGULAMASINDA PROFİLAKTİK İNTRAVENÖZ EFEDRİNİN YENİDOĞAN LAKTİK ASİT DÜZEYİNE ETKİSİ

The Effect Of Prophylactic Intravenous Ephedrine On Lactic Acid Level Of Neonate During Spinal Anesthesia For Caesarean Section

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
hirty healthy women undergoing elective caesarean section under spinal anaesthesia at term were allocated randomly to receive ephedrine infusion (grup I, n=15) (approximately 5mg/min) immediately after onset of sensory block or boluses of I. V 10 mg ephedrine (grup I, n=15) when maternal blood pressure decreased by more than 20% from baseline value. Maternal and newborn blood pressures and heart rates were recorded. Incidences of nausea and vomiting were compared between the groups. Maternal and neonatal acid-base status and lactic acid levels were compared between the groups. Systoiic blood pressure in the bolus group was significantly lower when compared to the infusion group (p<0.05). Nausea occurred in one patient (6%) in the infusion group, and nausea and/or vomiting occurred in 10 patients (66%) in the bolus group (p<0.05). Umbiiical artery pH was significantly lower in the bolus group (p<0.05), however no differences were observed in Apgar scores and fetal lactic acid level. As a result, although healthy parturients undergoing spinal anesthesia for caeserian section have severe hypotension, short hypotensive period is an important factor that protects the newborn against lactic acidosis.
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Abstract (Original Language): 
Çalışmamızda termde spinal anestezi lle elektif sezaryen uygulanacak 30 sağlıklı gebe rasgele iki gruba ayrıldı. Spinal anestezi sonrası duysal blok başlar başlamaz efedrin infüzyonu (yaklaşık 5mg/dk) uygulanan (grup I, n=15) veya annenin kan basıncı bazal değerden %20'den fazla azaldığında intravenöz bolus 10 mg efedrin verilenler (grup II, n=15) olmak üzere iki gruba ayrldı. Anne ve yenidoğanın kan basıncı lle kalp hızı kaydedlldi. Bulantı ve kusma insidansı belirlendi. Anne ve bebeğin asit-baz durumu ve lakta t düzeyleri karşılaşbnldı. Sistoiik kan basıncı bolus grubunda infüzyon grubuna göre anlamlı olarak düşüktü (p<0.05). İnfüzyon grubunda bir hastada bulantı (%6) bolus grubunda 10 hastada bulantı ve kusma %%66) görüldü (p<0.05). Umbiiikal arter pH'ı bolus grubunda belirgin olarak düşüktü (p<0.05), ancak her iki grup arasında yenidoğanın Apgar skoru ve kan laktik asit düzeyleri yönünden fark saptanmadı. Sonuç olarak, spinal anestezi ile sezaryen uygulanacak sağlıklı gebelerde hipotansiyon şiddetti olsa blle hipotansif kalma süresinin uzun olmaması yenidoğanı laktik asidozdan koruyan önemli bir faktördür.
FULL TEXT (PDF): 
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  • 4
287-291
  • Turkish

REFERENCES

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