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KRONİK ALKOL TÜKETİMİNİN SIÇANLARIN İLEUM MAST HÜCRE POPULASYONU ÜZERİNE ETKİLERİ

The Effect Of Chronic Alcohol Consumption On The ileum Mast Cell Population of Rats

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Aim: The present study was planned to investigate the effect of alcohol on the ileum mast cell population of rats at the light microscopic level. Methods: The experimental group was fed with a modified liquid diet (MLD) With containing 7.2 %of ethanol during six months. Control rats were fed by isocaloric MLD without ethanol. At the end of experimental feeding period samples were fixed in %10 formaldehyde and stained with %0.5 Toluidin blue and Haematoxylin Eosin. Mast cells in all section were counted using a magnifying ofX40. Results: In alcoholic rats mast cells degranulation and the number of the mitoses in the crypts were to be found increased. Conclusion: This study revealed that ileum mast cell population was significantly reduced in alcohol feeding group when compared with liquid diet group.
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Abstract (Original Language): 
Amaç: Bu çalışma alkolün, ince bağırsak mast hücre popülasyonu üzerine etkisinin ışık mikroskobu düzeyinde araştırılması için planlandı. Yöntem: Deney grubu %7.2 alkol içeren modifiye sıvı diyet (MSD), kontrol grubu ise alkolsüz MSD ile yaklaşık altı ay beslendiler. Deney sonunda alınan ileumlar %10 formol ile tespit edilip, %0.5'lik Toluidin blue ve Hematoksilen Eozin ile boy andı. Kesit/erdeki mast hücreleri X40 kullanılarak sayıldı. Bulgular: Alkolik sıçanlarda mast hücre degranülasyonu ve kriptlerdeki mitoz sayısında artış tespit edildi. Sonuç: Alkolik sıçanlardaki mast hücre popülasyonunun, sıvı- diyet kontrollerle karşılaştırıldığında önemli derecede azalmış olduğu bulundu.
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  • 1
63-66
  • Turkish

REFERENCES

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