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TOTAL İNTRAVENÖZ ANESTEZİ AMACIYLA KULLANILAN PROPOFOLÜN SERUM KOLESTEROL VE TRİGLİSERİD DÜZEYLERİNE ETKİSİ

The Effects Of Propofol Infusion On Serum Lipid Levels In Total Intravenous Anesthesia

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Because of the desirable cerebral effects of propofol, it is the preferred agent for neurosurgical operations. But it can also lead to increments of the lipid levels in the patients who are sedated with propofol for prolonged durations. Our aim was to determine the effect of intraoperative propofol infusion on serum lipid levels. Material and methods: Twelve patients (18-65 years of age) undergoing craniotomy operation were anesthetized with total intravenous technique using propofol, alfentanil and vecuronium bromide infusions while inhaling a mixture of 30 % 02 and 70 % N20. Blood samples were taken before the induction of anesthesia, two hours after the induction and on postoperative 8th and 24th hours to measure the serum cholesterol, TG, HDL, VLDL and LDL levels. Results: Comparing with the control values, serum cholesterol levels were significantly decreased in the peroperative Z"1 hour, postoperative 8th and 24* hours. Serum LDL levels were also significantly decreased in the postoperative 8th and 24* hours. TG and VLDL levels were significantly increased during propofol infusion in the intraoperative 2nd hour and decreased back to the control values after infusion. Serum HDL levels was not changed significantly in all measurements. Conclusion: As a conclusion, propofol in total intravenous anesthesia can be used safely even though there are temporary changes in serum lipid levels. But still, it should be used cautiously for the patients thought to be at particular risk of lipid overload.
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Abstract (Original Language): 
Amaç: Propofolün uzun süre infüzyonu sırasında serum lipid konsantrasyonlarında artışa neden olduğu bilinmektedir. Çalışmamızda intrakranial cerrahide propofol infüzyonunun serum lipid düzeylerine etkisini belirlemeyi amaçladık. Materyal Metod: İntrakranial cerrahi girişim geçirecek 18-65 yaşları arasında, (ASA I-II) 12 hasta çalışmaya dahil edildi. Hastalarda anestezi indüksiyonu; propofol, alfentanil, vekuron-yum bromid I.V. ile sağlandı. Anestezi idamesinde; propofol, alfentanil ve vekuronyum bromid infüzyonu uygulandı ve hastalar %30 02, %70 N20 ile mekanik olarak solutuldu. Total kolesterol, yüksek dansiteli lipoprotein (HDL), düşük dansiteli lipoprotein (LDL), çok düşük dansiteli lipoprotein (VLDL) ve trigliserid (TG) düzeylerinin belirlenebilmesi için; indüksiyon öncesi, indüksiyon sonrası 2. saat, postoperatif 8. ve 24. saatlerde kan örnekleri alındı. Bulgular: Serum kolesterol düzeyi peroperatif 2., postoperatif 8. ve 24. saatlerde indüksiyon öncesi değerine göre anlamlı olarak düşük saptanmıştır. LDL seviyesi 8. ve 24. saatlerde kontrol değerine göre anlamlı düşme saptanmıştır. Serum TG ve VLDL seviyeleri peroperatif 2. saatte kontrol değerlerine göre anlamlı olarak yükselmiş, postoperatif 8. ve 24. saatlerde kontrol değerlerine ulaşmıştır. Serum HDL düzeyinde anlamlı bir değişiklik saptanamamıştır. Sonuç: Her ne kadar serum lipid düzeylerini geçici olarak yükseltse de, intrakranial cerrahi sırasında propofolün, serebral oksijen kullanımı ve hemodinami üzerine bilinen olumlu etkileri nedeni ile güvenle kullanılabileceği; ancak serum lipid düzeyinin daha da yükselebileceği hastalarda dikkatli olunması gerektiği kanısındayız.
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  • Turkish

REFERENCES

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