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HİPERBARİK OKSİJENİN SIÇAN SOLUNUM SİSTEMİNDE OLUŞTURDUĞU DEĞİŞİKLİKLERDE VİTAMİN E VE C KOMBİNASYONUNUN ETKİSİ

The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations. Materials and Methods: Thirty adult rats were divided into three groups as control, HBO and HBO+Vit groups. Twenty animals in HBO and HBO+Vit groups were exposed to HBO on a daily basis for 45 days. Additionally, vitamin E and C were administered to the rats in the HBO+ Vit group intraperitoneal^ during HBO exposure. Results: Histologic examination in HBO group demonstrated epithelial thickening in the trachea, increase in the thickness of alveolar septae, emphysema and mononuclear cell infiltration in lung tissue. Vitamin administration in addition to HBO seemed to reduce the negative effects of HBO on the trachea and lungs of the rats. Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.
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Abstract (Original Language): 
Amaç: Bu çalışmada, sıçan solunum sisteminde hiperbarik oksijen (HBO) uygulamasıyla oluşan yapısal değişiklikler ve bu değişikliklere Eve C vitaminlerinin etkileri araştırıldı. Materyal ve Metot: Otuz yetişkin sıçan, kontrol, HBO ve HBO+Vit grupları şeklinde üç ayrı grupta incelendi. HBO ve HBO+Vit gruplarına 45 gün süreyle HBO uygulandı; HBO+ Vit grubuna ise ek olarak intraperitoneal yoldan Eve C vitaminleri verildi. Bulgular: HBO grubuna ait dokuların histolojik incelemelerinde, trakeada epitel kalınlaşması, akciğerde ise alveoler septumda kalınlaşma, amfizem ve mononükleer hücre infiltrasyonları izlendi. HBO ile beraber vitamin uygulamasının trakea ve akciğerde oluşan olumsuz etkileri azalttığı gözlendi. Sonuç: E ve C vitamin kombinasyonunun HBO'ya bağlı gelişen trakea ve akciğer doku hasarını azaltmada etkili olabileceği sonucuna varıldı.
FULL TEXT (PDF): 
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  • 2
153-157
  • Turkish

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