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İNFLAMATUVAR ROMATİZMAL HASTALIKLARDA EPSTEIN-BARR VE CYTOMEGALOVIRUS ANTİKOR POZİTİFLİĞİ

Epstein-barr and cytomegalovirus antibody positivities in inflammatory rheumatic diseases

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: Studies on the role of viruses on pathogenesis of the inflammatory rheumatic diseases for which autoimmune mechanisms have been believed to those play important roles, still have increased popularity. This study has been conducted to explore EBV-VCA and CMV antibody positivities in serum samples of patients with inflammatory rheumatic diseases such as RA and AS. Material and methods: The patients with RA (n=38) and AS (n=36) who admitted to outpatient clinics of the department of PM&R and 41 healthy volunteers were been included in this study. Serum EBV-VCA IgG and EBV-VCA IgM, and CMV IgG, IgM, and IgA antibodies were measured by ELISA as positive or negative results. Results: CMV IgA antibody positivities in patients with RA were higher than the control group; in addition EBV-VCA IgM antibody positivities were higher in the patients with RA than those with AS and healthy volunteers. Conclusion: These results suggest that EBV infections may play a role in etiopathogenesis of RA.
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Abstract (Original Language): 
Amaç: Etiyopatogenezinde otoimmün mekanizmaların sorumlu tutulduğu inflamatuvar romatizma! hastalıkların patogenezinde viral ajanların rolü ile ilgili çalışmalar popülaritesini korumaktadır. Bu nedenle inflamatuvar romatizma! hastalıklardan olan romatoid artrit (RA) ve ankilozan spondilit (AS) olgularının serumlarında Epstein-Barr Virus (EBV) ve Cytomegalovirus (CMV) antikor pozitifliklerinin saptanması amacı ile bu çalışma planlandı. Materyal ve metot: Hastanemiz FTR departmanı polikliniklerine başvurup klinik ve laboratuvar değerlendirmeler sonrası 387 RA ve 36'sı AS tanısı konmuş 74 olgudan oluşan hasta grubu ile, yaş ve cinsiyetleri uyumlu 41 sağlıklı bireyin oluşturduğu kontrol grubu çalışmaya dahil edildi. Her iki gruptaki olguların serumlarında; EBV-VCA IgG ve IgM ile CMV IgG, IgM ve IgA antikorlarının pozitifliği ELISA yöntemi ile araştırıldı. Bulgular: RA 7i olgularda CMV IgA pozitifliğinde kontrol grubuna göre (p=0.031), EBV-VCA IgM pozitifliğinde ise hem AS hem de kontrol grubuna göre (p=0.001) istatistiksel olarak anlamlı farklılıklar tespit edildi. Sonuç: Bu çalışmanın verileri, RA etiyopatogenezinde EBV infeksiyonlarının rol oynayabileceği görüşünü desteklemektedir.
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  • 2
141-143
  • Turkish

REFERENCES

References: 

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