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ETOFENAMAT'IN RANDOM PATERNLİ SIÇAN DORSAL DERİ FLEBİ YAŞAYABİLİRLİĞİ ÜZERİNE ETKİSİ

The Effect Of Etophenamate On The Survival Of Random Pattern Rat Dorsal Skin Flap

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Many skin flaps have been defined for the reconstruction of skin defects. Distal Hap necrosis is met as a serious problem especially while elevating long skin flaps. So many experimental and clinical studies have been done to prevent distal Hap necrosis and to improve the survival of skin Haps. In this experimental study, the effect of an anti-inflammatory agent, namely etophenamate on skin Hap survival rates has been investigated. In Sprague-Dawley rats, caudally based random pattern dorsal skin Hap including panniculus carnosus 3x10 cm in size were elevated and sutured back to its original place. In the control group, no pharmacological agent was given, and in the experimental group, etophenamate 10 mg/kg/day, IM, was administered for seven days postoperatively. On the seventh day, the surviving areas of the skin flaps were measured and the results were evaluated by Students t-test The survival rates of skin flaps were found as % 83. 27 in the etophenamate and % 65.70 in the control group. It was found that etophenamate increased the survival rates of skin Haps, statistically significant, comparing to that of control group (p<0.05). Biopsies were taken from the border between necrotic and surviving tissue, and histopathological evaluation was performed. On the histopathological evaluation, Histopathological evaluation showed an increase in vascularity beneath flap at border od necrotic tissue, and a decrease in infiltration of inflammatory cells.
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Abstract (Original Language): 
Deri defektlerinin rekonstrüksiyonu için birçok deri flebi geliştirilmiştir. Distal flep nekrozu, özellikle uzun deri flepleri kaldırılırken, önemli bir problem olarak karşımıza çıkmaktadır. Bu nedenle, distal flep nekrozunu önlemek ve Hep yaşayabilirliğini artırmak için birçok deneysel ve klinik çalışma yapılmıştır. Bu deneysel çalışmada, anti-inflamatuar ajan olan etofenamatın deri flebi yaşayabilirliği üzerindeki ekisi araştırıldı. Sprague-Dawley cinsi sıçanlarda, 3x10 cm boyutlarında pannikulus karnozus içeren kaudal tabanlı random paternli dorsal deri flebi kaldırılıp, yerine iade edildi. Kontrol grubuna herhangi bir farmakolojik ajan verilmezken, deney grubuna postoperatif dönemde yedi gün boyunca etofenamat 10 mg/kg/gün, IM olarak verildi. Yedinci günde deri Heplerinin yaşayan alanları ölçüldü ve sonuçlar "Student's t-test" ile değerlendirildi. Yaşayabilen flep oranları etofenamat grubunda % 83.27 ve kontrol grubunda % 65.70 olarak bulundu. Etofenamatın Hep yaşayabilirliğini, kontrol grubuna oranla, istatistiksel olarak anlamlı bir şekilde arttırdığı bulundu (p<0.05). Yedinci günde nekroz-canlı doku hattından biyopsi alındı ve histopatolojik değerlendirme yapıldı. Histopatolojik değerlendirmede, nekroz-canlı doku sınırında, her iki grupta da flep ile Hep yatağı arasında damar/anmada artış görülürken, deney grubunda kontrol grubuna oranla daha az inflamatuar hücre infıltrasyonu izlendi.
FULL TEXT (PDF): 
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  • 4
301-305
  • Turkish

REFERENCES

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Turgut Özal

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