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Serum 62-Mikroglobülin: Preeklampsinin Erken Tahminindeki Önemi

Serum 62-Microglobulin: It s Significance in The Prediction of Preeclampsia

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: The study was planned to determine whether or not, second trimester maternal serum levels of 82-microglobulin could be used to predict subsequent devolopment of preeclampsia. Study design: Serum 82-microglobulin levels of 7 nulliparous and 8 multiparous women with normotensive were determined nephelometrically. Blood samples were collected between 18 and 26 weeks gestation and those cases were followed up prospectively for subsequent devolopment of preeclampsia. Results: Mean maternal serum 82-microglobulin levels of 15 normotensive pregnant patients were found 1.00±0.10 mg /L. Fifteen normotensive women were followed up prospectively, two of them (13.3%) preeclampsia developed and 13 women remained normotensive (86.7%) throughout pregnancy. No difference between maternal serum 82-microglobulin levels of two patients with preeclampsia and 13 patients who remained normotensive during gestation was found (1.01±0.10mg/L vs 1.00±0.11 mg/L, p<0.02). Conclusion: Second trimester maternal serum 82-microglobulin levels can not be used as an predictive marker of subsequent preeclampsia. But, further in vivo and in vitro studies are needed to exactly clarify the effects and the role of serum 82-microglobulin levels in patients with preeclampsia
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Abstract (Original Language): 
Amaç: Bu çalisma ikinci trimester maternal serum 82-mikroglobülin düzeylerinin preeklampsi gelisiminin önceden saptanmasindaki prediktif değerini arastirmak için planlandi. Materyal Metod: Onsekiz ve 26. gestasyonel haftalar arasinda gebeliği bulunan 7 nullipar ve 8 multipar olmak üzere toplam 15 normotansif hastanin maternal serum 82-mikroglobülin düzeyleri nefelometrik olarak saptandi. Hastalar gebelikleri terme ulasana kadar aylik olarak takip edildi. Yapilan takiplerinde preeklampsi gelisenler ile gelismeyenlerin maternal serum 82- mikroglobülin düzeyleri karsilastirildi. Bulgular: On bes hastanin ortalama maternal serum 82-mikroglobülin düzeyleri 1.00±0.10 mg /L olarak saptandi. Bu hastalarin yapilan takiplerinde sadece 2 hastada preeklampsi gelisirken (%13.3), 13 hasta normotansif olarak kaldi (%86.7). Preeklampsi gelisen 2 hastanin maternal serum 82-mikroglobülin düzeyleri ile preeklampsi gelismeyen 13 hastanin maternal serum 82-mikroglobülin düzeyleri arasinda herhangi bir fark bulunamadi (1.01±0.10mg/L, 1.00±0.11 mg/L, p<0.02). Sonuç: Bu çalismada ikinci trimester serum 82-mikroglobülin düzeyleri preeklampsi gelisiminin önceden tanisinda kullanilabilecek güvenilir bir marker olarak bulunmamistir. Ancak serum 82-mikroglobülin düzeylerinin preeklamptik hastalardaki etki ve rolünü kesin olarak açiklamak için daha ileri in vivo ve in vitro çalismalara ihtiyaç vardir.
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  • 1
49-52
  • Turkish

REFERENCES

References: 

1. Shaarawy M, El Meleigy M, Rasheed K. Maternal serum transforming growth factor beta-2 in preeclampsia and eclampsia, a potential biomarker for the assessment of disease severity and fetal outcome. J Soc Gynecol investig. 2001; 8:27-31.
2. Haddad B, Desvaux D, Livingston JC, Barranger E, Paniel BJ, Sibai BM. Failure of serum beta2-microglobulin levels as an early marker of preeclampsia. Am J
Obstet Gynecol 2000;182:595-8.
3. Faden D, Tincani A, Tanzi P, Spatola L, Lojacono A, Tarantini M, Balestrieri G. Anti-beta2 glycoprotein I antibodies are associated with some obstetrical complications, mainly preeclampsia-eclampsia. Eur J Obstet Gynecol Reprod Biol 1997;73:37-42.
4. Aune B, Vartun A, Oian P, Sager G. Evidence of dysfunctional beta2-adrenoceptor signal system in pre-eclampsia. BJOG 2000;107:116-21.
5. Tian G, Huang Q, Yu H. Clinical significance of changes of urinary enzymes in pregnancy induced hypertension. Zhonghua Fu Chan Ke Za Zhi 1996;31:465-7.
6. Katano K, Aoki A, Sasa H, Ogasawara M, Matsuura E, Yagami Y. Beta 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod 1996;11:509-12.
7. Redline RW, Patterson P. Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 1995;26:594-600.
8. Erkkola R, Sjöberg NO. Can pre-eclampsia be predicted and prevented? Acta
Obstet Gynecol Scan Supp 1997; 76:98-100.
9. Mushambi MC, Halligan AW, Williamson K. Recent developments in the pathophysiology and management of pre-eclampsia. Br J Anaesth 1996; 76:133¬148.
10. Lockwood CJ, Rand JH. The immunobiology and obstetrical consequences of antiphospholipid antibodies. Obstet Gynecol Surv 1994;49:432-41.
11. Zahradnik HP, Moller K, Stumme H, Casper FW, Seufert R, Schafer W.
Prostaglandins in the urine of hypertensive pregnant patients. Zentralbl Gynakol
1994;116:337-9
12. Zhang SJ. Urinary minor proteins, beta 2-microglobulin (beta 2-MG) assay with pregnancy induced hypertension. Zhonghua Fu Chan Ke Za Zhi 1993;28:706-8,
758
13. Yamamoto T, Yoshimura S, Geshi Y, Sasamori Y, Okinaga S, Kobayashi T, Mori H. Measurement of antiphospholipid antibody by ELISA using purified beta2-glycoprotein I in preeclampsia. Clin Exp Immunol 1993;94:196-200
14. Saudan PJ, Farrell TJ, Brown MA. Beta2-microglobulin in hypertensive
pregnancies. Am J Kidney Dis 1998;31:308-12.

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