Buradasınız

Anasayfa » Content

Konjenital VSD'li Çocuklarda QT ve QTc Dispersiyon Değerleri

The Values Of QT And QTc Dispersion In Children With Congenital Ventricular Septal Defect

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The QT interval dispersion has long been known to be a marker of dispersion of ventricular repolarisation or electrical instability. Additionally, it has previously been shown that congenital ventricular septal defects (VSD) occasionally induce a QRS axis shift. There is no knowledge about QT and QTc dispersion indicating inhomogenous myocardial repolarization in the patients with VSD. In this study, we examined the values of dispersion of ventricular repolarization in the patients with VSD. We examined 21 patients (mean age;6±2 years, 9M, 12F) with VSD and 26 age matched healthy subjects as the control group (mean age;9± 3 years, 14M, 12F). We found QTd and QTc-d intervals of 54.2 ± 12.2 ms, 72,4 ± 9.2 ms in the patients withVSD, where the values for control group were 45.1 ± 11.3ms and 61.5 ± 6.7ms respectively (for all, P< 0.05). Important increase in QT and QTc dispersion indicating inhomogenous myocardial repolarization were noted in patients with VSD. In conclusion the data of this study suggest that the patients with VSD appear to have repolarization abnormalities, reflected by an increase in QT and QTc dispersion. This finding may be important in the explanation of ventricular repolarization abnormalities in patients with VSD.
Bookmark/Search this post with
Abstract (Original Language): 
QT interval dispersiyonunun , ventriküler repolarizasyon dispersiyonu veya elektriksel instabilitenin bir göstergesi olduğu uzun zamandır bilinmektedir. Ayrıca, konjenital ventriküler septal defektlerin (VSD) bazen QRS aks değişikliğine neden olduğu daha önceden belirlenmiştir. VSD'si olan hastalarda ventriküler repolarizasyon heterojenitesini gösteren QT ve QTc dispersiyonu hakkında hiçbir bilgi yoktur. Bu çalışmada, konjenital VSD olanlar çocuklarda ventriküler repolarizasyon dispersiyon değerlerini araştırdık. Çalışma VSD'si olan 21 hastayı (ortalama yaş;6± 2yıl, 12 E, 9 K) ve kontrol grubu olarak 26 sağlıklı çocuğu (ortalama yaş;9± 3yıl, 14 E, 12 K) içeriyordu. VSD'si olan hastalarda QT ve QTc dispersiyon değerleri sırasıyla 54.2+/-12.2, 72.48+/- 9.2 ms iken kontrol grubunda bu değerler sırasıyla 45.1+/- 11.3ms, 61.5+/-6.7 ms olduğunu bulduk (tümü için p < 0.05). VSD'si olan hastalarda homojen olmayan miyokardiyal repolarizasyonu gösteren QT ve QTc dispersiyon değerlerinde önemli artışlar olduğu kaydedildi. Sonuç olarak, bu çalışma konjenital VSD'i olan hastaların QT ve QTc dispersiyonunun artması olarak yansıyan repolarizasyon anormalliklerine sahip olduğunu ortaya çıkarmıştır. QT ve QTc dispersiyonunun artması VSD''i olan hastalarda ventriküler repolarizasyon anormalliklerinin açıklanmasında önemli olabilir.
FULL TEXT (PDF): 
PDF icon arastirmax-konjenital-vsdli-cocuklarda-qt-qtc-dispersiyon-degerleri.pdf
  • 4
241-243
  • Turkish

REFERENCES

References: 

1. Lepeschkin E, Surawics B. The measurement of the QT interval of the electrocardiogram. Circulation 1952;6:378-88.
2. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-4.
3. Statters DJ, Malik M, Ward DE, Camm AJ. QT dispersion : problems of
methodology and clinical significance. J Cardiovasc Electrophysiol 1994;5:672-85.
4. Higham PD, Campbell RW. QT dispersion. Br Heart J 1994;71:508-10.
5. Swensson RE. QRS axis in isolated perimembranous ventricular septal defect. J
Electrocardiol 2001 ;34(3):205.
6. HE Tutar et al. QRS axis in isolated perimembranous ventricular septal defect and influences of morphological factors on QRS axis. J Eloctrocardiol 2001;34(3):197-
203.
7. Jervell A, Lange. Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death. Am Heart J 1957; 54:59-68.
8. Romano C, Gemme G, pongiglione R Aritmie cardiache rare dell' eta'pediatrica.
Clinica Pediat 1963;45:656-683.
9. Schwartz PJ: Idiopathic long QT syndrome. Progress and question. Am Heart J
1985;109:399-411.
10. Ward OC: A new familial cardiac syndrome in children. J Irish Med Assoc
1964;54:103-106.
11. Schwartz PJ, Wolf S: QT interval prolongation as predictor of sudden death in patients with mycardial infarction. Circulation 1978;57:1074-77
12. De Ambriogg L, Negroni MS, Monza E, Bertoni T, Schwartz PJ. Dispersion of ventricular repolarisation in the long QT syndrome. Am J Cardiol 1991;68:614-20.
13. Kuo CS, Munakata K, Reddy CP, Surawicz B. Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations.
Circulation 1983;67:1356-67.
14. Puddy PE, Bourassa MG; Prediction of sudden death from QTc interval prolongation in patients with chronic ischemic heart disease. J Electrocardiol 1986;19:203-212.
15. Bazett HC. An analysis of the time-relations of electrocardiogram. Heart 1920;7:353-
70.
16. Surawicz B, Knoebel SB. Long QT: good, bad or indifferent?.J Am Coll Cardiol
1984;4:398-413.
17. Morganrothh J. QTc interval prolongation: is it beneficial or harmful? Am J Cardiol
1993;72:1B-59B.
18. Merx W, Yoon MS, Han J. The role of local disparity in conduction and recovery time on ventricular vulnerability to fibrillation. Am Heart J 1977;94:603-10.
19. Abildskov JA, Burgess MJ, Urie PM, lux RL, Wyatt RF. The unidentified content of the electrocardiogram. Circ Res 1977;40:3-7.

Thank you for copying data from http://www.arastirmax.com