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ASSESSMENT OF SYMPATHOVAGAL RESPONSE TO VARIOUS PHYSIOLOGICAL STIMULI IN PREHYPERTENSIVE AND HYPERTENSIVE INDIVIDUALS.

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DOI: 
10.5958/j.2319-5886.2.3.079
Abstract (2. Language): 
Background : It is well known that there is correlation between autonomic nervous system and blood pressure. Sympathetic hyperactivity is the major cause for the pathogenesis of hypertension. This study is undertaken to analyse the sympathovagal response to various physiological stimulus in both prehypertensive and hypertensive individuals. Aim: To compare the sympathovagal response in prehypertensive and hypertensive individuals. Materials & Methods : Around 40 subjects were selected and they were divided into 2 groups. Group 1 – prehypertensive, Group 2 - hypertensive 20 in each group. Orthostatic test and Cold pressor test were done to assess the sympathovagal balance. Results: There was a significant increase (p<0.5) in systolic and diastolic blood pressure in both prehypertensive and hypertensive to cold pressor test. The response of blood pressure to orthostatic test showed no significant difference in both hypertensive and prehypertensive individuals. Conclusion: The rise of both systolic and diastolic blood pressure was slightly higher in prehypertensive than hypertensive a individual which indicates sympathetic impairment in prehypertension and sympathetic failure in hypertension. Prehypertensives who showed sympathetic hyperactivity to cold pressor test may develop hypertension in later life.
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REFERENCES

References: 

1. Nalina N, Venkatesh D, Jaisri G.
Autonomic reactivity in normotensive
children of hypertensive parents.
Biomedicine. 2012;32:45-51.
2. Murray CJ, Lopez AD. Mortality by cause
for eight regions of the world. Global Burden
of disease study. Lancet 1997;349:1269-76
3. Kalpan NM. Systemic hypertension:
mechanisms and diagnosis. Braunwald’s
heart disease : a textbook of
cardiovascular medicine.7thed .Philadelphia:
Elsevier Saunders. 2005:959-87.
4. Cole RC, Lauer MS, Bigger JT. Clinical
assessement of the autonomic nervous
system.In: Topol EJ editor. Textbook of
cardiovascular medicine .2nd ed.
Philadelphia: Lippincott Williams &
Wilkins;2002.p.1615-32
5. Parati G, Rienzo Di M, Omboni S et al.
Computer analysis of blood pressure and
heart rate variability in subjects with normal
and abnormal autonomic cardiovascular
control ,chapter 22.211-223.
6. Matthews KA ,Woodall KL, Allen
MT.cardiovascular reactivity to stress
predicts future blood pressure status.J
Hypertension.1993;22:479-485.
7. Oparil S, Zaman MA, Calhoun DA,
Pathogenesis of hypertension.Annals of
Internal Medicine.2003;139;761-776. 18.
8. Pagani M, Lucini D.Autonomic
dysregulation in essential hypertension:
insight from heart rate and arterial pressure
variability. Auton Neurosci. 2001;90:76-82.
9. Chobanian AV, Bakrish GL, Black HR,
Cushman WC, Green LA,Izzo Jr,et al.
Seventh report of the joint National
Committee on prevention, Detection,
462
Nirmala etal., Int J Med Res Health Sci. 2013;2(3):458-462
Evaluation, and Treatment of High Blood
Pressure. Hypertension. 2003;42:1206-52
10. Mancia G, De Backer G, Dominiczak
A,Cifkova R, Fagard R, Germano G, et al.
Guidelines for the management of arterial
hypertension:T he Task Force for the
management of Arterial Hypertension of
the European Society of hypertension(ESH)
and of the European Society of
cardiology(ESC). Eur Heart J. 2007;28:1462-
536.
11. Vasan RS, Lason MG, Leip EP, Kannel
WB, Levy D. Assessment of frequency of
progression to hypertension in nonhypertensive
participants in Framingham
Heart Study: a cohort study. Lancet
2001;358:1682-6
12. Farah Khaliq, Keshav Gupta, Pawan Singh.
Autonomic reactivity to cold pressor test in
prehypertensive and hypertensive medical
students. Indian J Physiol Pharmacol
2011;55:246-252.
13. Kotchen TA. Hypertensive vascular
disease. Harrison’s principle of internal
medicine
2008. 17th ed. Mc Graw Hills; Chapter 241:
1549-62.
14. Seventh report A joint National
Committee on prevention & detection,
Evaluation & treatment of high Blood
Pressure, J Hypertension. 2003; 42: 1206-52
15. Ryder REJ, Hardisty CA. battery of
cardiovascular autonomic function tests.
diabetologia 1990;33:177-179.
16. Ewing DJ,Martyn CN ,Young RJ, Clarke
BF. The value of cardiovascular autonomic
function tests:10 years experience in
diabetes care 1985;8:491-498.
17. Wouter wieling and John M.Karemaker,
Measurement oh heart rate and blood
pressure to evaluate disturbances in
neurocardiovascular control, capter 2000:21:
197-210.
18. Lindqvist A, Torffvit O. Rittner R, Agardh
CD, Pahlm O. Artery blood pressure
oscillation after active standing up; an
indicator of sympathetic function in diabetic
patients. Cli. Physiol. 1997;17: 159-69.
19. Low PA. Clinical autonomic testing report of
the therapeutics and technology assessment
subcommittee of the American academy of
neurology. Neurology .2002; 46: 873-80.

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