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DENDRIMER: POLYMER OF 21st CENTURY

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The review aims majorly on four areas namely: Architecturing, Synthesis, f( Properties & Applications of the dendrimer. The unique architectural design of dendrimers, high degree of branching, multivalency, globular architecture and well-defined molecular weight, clearly distinguishes these structures as unique and optimum nanocarriers in medical applications such as drug delivery, gene transfection, tumor therapy, diagnostics, etc. Synthetic approaches lead to a dendritic architecture with properties amenable to modifications of shape, size, polarity, surface properties and internal structure. Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimer such as Polyester dendrimer, Citric acid dendrimer, Arginine dendrimer, Glycodendrimers, PEGylated dendrimers, etc. The bioactive agents can be easily encapsulated into the interior of the dendrimers or chemically attached i.e. conjugated or physically adsorbed onto the dendrimer surface, serving the desired properties of the carrier to the specific needs of the active material and its therapeutic applications. In addition to supplying a multivalent backbone for drug attachment, dendrimers also provide access to various new polymer architectures that are potentially relevant to drug delivery applications
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