Buradasınız

Anasayfa » Content

DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND DICLOXACILLIN SODIUM IN COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first order derivative spectrophotometric method for the simultaneous determination of Dicloxacillin sodium and Cefpodoxime Proxetile in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 237.2nm (ZCP of Cefpodoxime proxetil) for dicloxacillin sodium and 307.8 nm (ZCP of Dicloxacillin sodium) for Cefpodoximeproxetil. The linearity was obtained in the concentration range of 10¬90 ug/ml for cefpodoxime proxetil and 50-200 ug/ml for Dicloxacillin sodium. The mean recovery was 98.71-102.77% and 98.69-99.62% for cefpodoxime proxetil and dicloxacillin sodium, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of cefpodoxime proxetil and dicloxacillin sodium in pharmaceutical combined tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-development-and-validation-first-order-derivative-spectrophotometric-method-simultaneous-estimation-cefpodoxime-proxetil-and-dicloxacillin-sodium-combined-tablet-dosage.pdf
  • 2
  • English

REFERENCES

References: 

1.
Maryadele
an
d Neil JO: The Merck Index, an Encyclopaedia of Chemicals, Drugs and Biological. 14th Ed. New Jersey: Published by Merck Research Laboratories. Division of Merck and Co. Inc. Whitehouse station; 2006. P. 523.
2.
Swee
t man SC Eds: In the Martindale. The Complete Drug Reference. 35th ed. London: Pharmaceutical Press; 2007. P. 237.
3.
Th
e United State Pharmacopeia. USP30-NF24. Rockville MD: United State Pharmacopeia Convention. Inc; 2007. P. 1924-25
4. European Pharmacopoeia, 5th edition, 2005; p. 1422
5.
Alderete
a O, Gonzalez-Esquivelb DF, Riveroa LM and Torres NC: Liquichromatographic assay for dicloxacillin in plasma. Journal of Chromatography B 2004; 805: 353¬356.
6.
Basili
o M: Second-derivative spectrophotometric assay of mixtures of dicloxacillin sodium and ampicillin sodium in pharmaceuticals" Journal
of Pharmaceutical Sciences. 1988; 77: 1042-1046.
7.
Baro
t T, Patidar K, Kshartri N and Vyas N: Development and Validation of LC Method for the Determination of Ampicillin and Dicloxacillin in Pharmaceutical Formulation Using an Experimental Design. E-Journal of
Chemistry. 2009; 6: 955-964.
8.
Kathiresa
n K, Murugan R, Hameed SM, Inimai GK and Kanyadhara T: Analytical Method Development and Validation of Cefixime and Dicloxacillin Tablets by RP- HPLC. Rasayana Journal of Chemistry. 2009;
2: 588-592.
9.
Zhan
g MJ, Zhang HJ, Guan X and Xiao ZH: HPLC determination of dicloxacillin and amoxicillin in human plasma. Yaowu Fenxi Zazhi,
2006; 26: 228-231.
10. Maryadele
an
d Neil JO: The Merck Index, an Encyclopaedia of Chemicals, Drugs and Biologicals. 14th ed. New Jersey: Published by Merck Research Laboratories, Division of Merck and Co., Inc. Whitehouse station. 2006. P.
319.11. Sweetman SC, Eds. In The Martindale. The Complete Drug Reference. 35th ed. London: Pharmaceutical Press; 2007. P. 207.
12. Indian Pharmacopeia. Vol. III. New Delhi: The Controller Publication. Govt. of India; 2010. P. 1018.
13. The United State Pharmacopeia.
USP30-NF25. Rockville MD: United
State Pharmacopeia Convention. Inc;
2007. P. 1673-75
14.
Darj
i BH, Shah NJ, Patel AT, Patel NM: Development and validation of a HPTLC method for the estimation of cefdoxime proxetil. Indian J Pharm
Sci. 2007; 69: 331-333.
15. Singh S, Dubey N, Jain D, Tyagi
L and Singh M: Spectrophotometric
and RP- HPLC methods for
simultaneous determination of cefdoxime proxetil and lavulanate potassium in combined tablet dosage form. American-Eurasian Journal of
Scientific Research. 2010; 5: 88-93.
16. Gandhi SV, Patil UP, Patil
NG: Simultaneous Spectrophotometric determination of Cefdoxime proxetil and Potassium clavulanate. Hindustan Antibiot Bull. 2009; 51: 24-28.
17. Beckett H, Stenlake JB: Practical Pharmaceutical Chemistry. 14th ed. CBS Publishers and distributors. 1997.
P. 297-299.
18. The International Conference on Harmonization, Q2 (R1), Validation of Analytical Procedure, Text and Methodology. 2005.

Thank you for copying data from http://www.arastirmax.com