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DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION SPECTROPHOTOMETRY METHOD FOR SIMULTANEOUS ESTIMATION OF NAPROXEN AND ESOMEPRAZOLE MAGNESIUM TRIHYDRATE IN TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of Naproxen and Esomeprazole Magnesium trihydrate. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 276 nm and 302 nm, X max of Naproxen and Esomeprazole Magnesium trihydrate respectively. Beer's law was obeyed in the concentration range of 10-35 |ig/ml and 1-11 ]ig/ml for Naproxen and Esomeprazole magnesium trihydrate respectively. The mean % recoveries were found to be in the range of 99.26 -100.35 % and 98.89 - 99.33 % for Naproxen and Esomeprazole Magnesium trihydrate respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of Esomeprazole Magnesium trihydrate and Naproxen in their combined Tablet dosage form.
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