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EFFECT OF DIFFERENT POLYMERS AND STORAGE TEMPERATURE ON DRUG RELEASE FROM SALBUTAMOL SULPHATE LOADED MICROSPHERES PREPARED BY USING W/O EMULSION SOLVENT EVAPORATION TECHNIQUE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
This study was aimed to formulate and evaluate controlled release preparations of salbutamol sulphate microspheres by w/o emulsion technique using ethyl cellulose as the rate retardant material. Microspheres were prepared by water in oil emulsion technique using methanol solvent system and span 80 was used as the surfactant. Different polymers [hydroxypropyl methyl cellulose (HPMC15 cps) and methacrylic polymers (Eudragit E100, Eudragit L100)] were used to modify the release characteristics of salbutamol sulphate. Scanning electron microscopy (SEM) was performed to study the size, shape and surface morphology of the prepared microspheres. The size distribution of microsphere batches generally ranged from 204 urn to 582.3 |im with geometric means close to 600 |um. The best fit release kinetics was first order when hydroxyl propyl methyl cellulose (HPMC15) was used and Higuchi plot was followed in case of eudragid E100 and eudragid L100. Korsmeyer equation was used to calculate the release exponent value (n) which indicates the drug release behavior and the mean dissolution time (MDT) for release rate. The release of salbutamol sulphate was influenced by altering the polymer where drug release was found to be fickian diffusion controlled. The drug release profile of different formulations was changed with temperature while kept unde r two different storage temperatures of 60°C and 100°C.
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