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EFFECTS OF BITTERGOURD ON GLUCOSE TOLERANCE, OXIDATIVE STRESS AND BLOOD PRESSURE IN FRUCTOSE INDUCED DIABETIC RATS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
Bitter melon (Momordica charantia) or bittergourd commonly known as karella, (family ^ Cucurbitaceae), has been proved for hypoglycaemic effects. The objective of the present study was to evaluate effects of bittergourd (momordica charantia) on glucose tolerance, oxidative stress and blood pressure in fructose induced diabetic rat. Wister rats were made diabetic by fructose diet for 6 week. Animals were divided in to tw( groups. One as diabetic control and other one group was treated by 400mg/kg bitter gourd alcoholic extract fo next 2 weeks. After 8 weeks treatment they were checked for glucose tolerance, oxidative stress and blood pressure. The significant improvement in bitter gourd alcoholic extract treated group compare to diabetic group was found. So, from present study it is concluded that bitter gourd fruit has has beneficial effects on glucose tolerance, oxidative stress and blood pressure in fructose induced diabetic rats.
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REFERENCES

References: 

1. International Diabetes Federation. IDF diabetes atlas. 4th ed. Brussels, Belgium: International Diabetes Federation; 2009. Available from: www.diabetesatlas.org. Accessed 2010 May 31.
2. Wilson PW: Diabetes mellitus, and coronary heart disease. Endocrinol Metab Clin NorthAm 2001; 30: 857-881.
3. Stamler J, Vaccaro O, Neaton JD, and Wentworth D: Diabetes, other risk factors, and
12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 434-444.
4. Sowers JR, Epstein M, and Frohlich ED: Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001; 37: 1053-1059.
5. Lteif AA, Mather KJ, and Clark CM: Diabetes and heart disease an evidence-driven
guide to risk factors management in diabetes. Cardiol Rev 2003; 11: 262-274.
6. Bakris G, Sowers J, Epstein M and Williams M: Hypertension in patients with diabetes. Why is aggressive treatment essential? Post grad Med. 2000; 107: 53- 6,
61-4.
7. Epstein M and Sowers JR: Diabetes mellitus and hypertension. Hypertension .1992; 19: 403-18.
8. Weir MR. Diabetes and hypertension: blood pressure control and consequences. Am J Hypertens. 1999; 12(12 Pt 1-2): 170S-8S.
9. Yeh, GY, Eisenberg DM, Kaptchuk, TJ and Phillips RS: Systemic review of herbs and dietary supplements for glycemic control in
diabetes. Diabetes Care, 2003; 26 (4): 1277¬1294.
10. Platel K and Srinivasan K: Plant foods in the management of Diabetes mellitus: Vegetables as potential hypoglycaemic agents. Nahrung , 1997; 41: 68-74
11. Ahmed I: Effects of Momordica charantia fruit juice on experimental diabetes and its complications. , University of Central Lancashire, 1999
ISSN: 2277-8713
-390 IJPRBS
12. Welihinda J, Karunanayake EH, Sheriff MHR and Jayasinghe KSA: Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol
1986;17: 277-282,
13. Ahmed I, Lakhani MS, Gillett M, John A and Raza H. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced rats. Diabetes Research and Clinical Practice, 2001; 51: 155-161.
14. Akhtar MS, Athar MA and Yaqub M: Effect of Momordica charantia on the blood glucose level of normal and alloxan diabetic
rabbits. Planta Medica, 1981; 42, 205-212
15. Cakici I, Hurmoglu C, Tunctan B, Abacioglu N, Kanzik I and Sener B: Hypoglycemic effect of Momordica charantia extracts in normoglycemic or cyprohepta-diene induced hyperglycemic mice. Journal of
Ethnopharmacology, 1994; 44: 117-121.
16. Rao BK, Kesavulu MM and Apparao C: Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic mice. Journal of Ethnopharmacology. 2001; 78: 67-71.
17. Lotlikar, MM and Rajarama RMR: Pharmacology of a hypoglycemic principle: Isolated from the fruits of Momordica
charantia Linn. Indian Journal of Pharmacy, 1966; 28, 129-133.
18. Matsuda H, Li Y, Murakami T, Matsumura
N, Yamahara J and Yoshikawa M: Antidiabetic principles of natural medicines III structure-related inhibitory activity and action model of oleanolic acid glycosides on hypoglycemic effect. Chemical and Pharmaceutical Bulletin, 1998; 46, 1399-1403.
19. Khanna P, Jain SC, Panagariya, A and Dixit VP: Hypoglycemic activity of polypeptide-P from a plant source. Journal of
Natural Products, 1981; 44(6), 648-655.
20. Nag B, Medicherla S and Sharma SD:
Orally active fraction of Momordica charantia, active peptides thereof, and their use in the treatment of diabetes. US Patent 2000;
6127338.
21. Zhang SY, Yao and Lei QJ: Isolation, purification and characterization of peptides with hypoglycemic effect in Momordica Charantia L. Acta Biochimica et Biophysica Sinica, 1980; 12(4), 391
22. Ohkawa H, Ohishi N and Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Bio chem. 1979; 95: 351-358.
ISSN: 2277-8713 IJPRBS
23. Beutler
E
, Duron O and Kelly B. Reduced glutathione estimation. J Lab. Clin. Med. 1963; 61: 882.
24.
Misr
a HP and Frodvich I: The role of superoxide anion autoxidation of epinephrine and a simple for superoxide dismutase. J. Biol. Chem 1984; 247(10): 3170-3175.
25.
Aeib
i H and Bergmeyer H: Methods in enzymatic analysis. 2nd edition, New York, Academic Press 1974; 3: 673.
26. Lowry OH, Rosenbrouch NJ, Farr AL and Randall RJ: Protein measurement with folin phenol reagent. J. Biol. Chem 1951; 193:
265-275.
27. Sleder J, Chen, YDI, Culli MJ and Reaven
GM:
Hyperinsulimeni
a in fructose induced hypertriglycerdemia in the rat. Metabolism. 1981; 29: 303-305.
28. Elliot SS, Kein NL, Stern JS and Havel PJ,
Fructose, weight gain and the insulin resistance syndrome. American Journal of Clinical
Nutrition. 2002; 76: 911-922.
29. Ahmed I, Cummings E, Adeghate E, Sharma AK and Singh J: Beneficial effects and mechanism of action of Momordica charantia fruit juice in the treatment of streptozotocin-induced diabetes mellitus in rats. Mol Cell
Biochem. 2004; 26: 63-70.
30. Masatoshi Sasa, Ikuo Inoue, Yuichi Shinoda, Seiichiro takahashi, makota Seo,Tsugikazu Komoda, Takuya Awata, and Shigehiro Katayama: Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPAR 5. Journal of Atherosclerosis and
Thrombosis. 2009; 16: 6:888.
31. Ramadhar K, Balaji S, Uma TS and Sehgal PK: Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPARy and PI3K. Journal of Ethnopharmacology. 2009; 126: 533-537.
32. West IC: Radicals and oxidative stress in
diabetes. Diabet Med 2000; 17: 171-80.
33. Nishikawa T, Edelstein D and Brownlee M: The missing link: a single unifying mechanism for diabetic complications. Kidney
Int Suppl 2000; 77: S26 -S30.
34. Evans JL, Goldfine ID, Maddux BA and Grodsky GM: Are oxidative stress-activated signaling pathways mediators of insulin resistance and b-cell dysfunction? Diabetes 2003; 52: 1- 8.
35. Basciano H, Federico L and Adeli K: Fructose, insulin resistance, and metabolic dyslipidemia. Nutr. Metab. (Lond). 2005; 2: 5.
36. Hsieh PS: Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats. J. Hypertens 2005;
23: 2209-2217.
37. Verma S, Bhanot S and McNeill JH: Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension. Eur. J.
Pharmacol. 1999; 373: R1-R4.
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