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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND INDAPAMIDE IN THEIR COMBINED TABLET DOSAGE FORM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The Present manuscript describes two simple, accurate, precise, economical, reproducible and specific spectrophotometric methods have been developed for simultaneous determination of Olmesartan Medoxomil (OLM) and Indapamide (IND) in its combined tablet dosage form by using methanol as a solvent. The first method is Q absorption method which involves Amax 241 nm (Amax of IND) and isoabsorptive point at 285.24 nm. The second method simultaneous method in which absorption at 286.78 nm (AMax of IND) was used for quantification of OLM and 256.40 nm (AMax of OLM) was used for quantification of IND. Two methods follow Beer's linearity in the range of 5-55 ug/ml and 1-25 ug/ml for OLM and IND both. The mean % recoveries were found to be in the range of 99.06 - 101.11 % and 98 -100.77 % for OLM and IND respectively for Q- absorption method and in the range of 99.72 - 102.88% and 98 - 101.58% OLM and IND respectively for simultaneous method. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of OLM and IND in their combined Tablet dosage form. The results of analysis have been validated statistically and also by recovery studies. Thus the present study gives an excellent method for the determination of all the two drugs in combined dosage formulation without their prior separation.
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  • 5
485-501
  • English

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accepted in International Journal of (IJPPS) vol 4 suppl4/4432.pdf
Available Online

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