Buradasınız

Anasayfa » Content

EVALUATION OF ANTI-INFLAMMATORYACTIVITY OF TINOSPORACORDIFOLIA: ROLE IN ARTHRITIS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Objectives: To evaluate the anti-inflammatory Tinosporacordifolia in experimentally induced inflammation in albino rats. Methods: The study was conducted on albino rats (150-200 gm) of either sex. Inflammation was induced by non-immunological (acute, sub acute, chronic) and Immunological methods. For each set of experiment, animals were divided in five groups of six animals each. 1st group was given normal saline, 2nd group standard anti inflammatory drug and 3rd, 4&5th group Tinosporacordifolia (T. cordifolia) in doses of 100, 200 &400 mg/kg respectively. In both experiments, inflammation was measured by standard methods. Results: In both Non-immunological (acute, sub acute, chronic) &immunologically induced inflammation T. cordifolia treated groups show significant anti-inflammatory activity in comparison to control group Conclusion: T. cordifolia exhibited significant and promising antiinflammatory activity in all the experimental models covering the different phases of inflammatory response.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon 9-14-34-ijprbs-161.12.pdf
  • 5
193-204
  • English

REFERENCES

References: 

1. Hench PS, Kendall EC, Slocumb CH and
Polley HF: The effect of a hormone of the
adrenal cortex (17-hydrooxy-11-dehydrocorticosterone;
compound E) and of
pituitary adrenocorticotropic hormone on
rheumatoid arthritis. Proc Staff Meet Mayo
Clin 1949; 24: 181.
2. Richard AH and Pamela CC: Adrenal
corticosteroids. 4th ed. Lippincott’s
illustrated reviews of pharmacology.
Baltimore, Maryland. 2009; 316.
3. Nikander R, McMohan FG and Ridolfo
AS: Non steroidal anti-inflammatory
agents. Ann Rev Pharmacoltoxicol 1979;
19:469-90.
4. Shawn XS, Kwan YL, Carl TB and Jay LG:
Withdrawal of COX-2 selective inhibitors
rofecoxib and valdecoxib: impact on NSAID
and gastro protective drug prescribing and
utilization. Current Medical Research and
Opinion 2007; 23: 1859-66
5. KirtiSinha, N P Mishra, J Singh and SPS
Khanuja: Tinosporacordifolia (Guduchi), a
reservoir plant for therapeutic applications:
A Review. Indian Journal of Traditional
Knowledge. 2004; 3: 257-270.
6. Winter CA, Risley EA and Nuss GW:
Carrageenan induced edema in the hind
paw of the rats as assay for antiinflammatory
drugs. Proc Soc Exp Biol Med
1962; 111: 544-7.
7. Harris JM and Spencer PSJ: A modified
plethymographic apparatus for recording
volume changes in the rat paw. J Pharm
Pharmac 1962; 14:464-466.
8. Kellet DN: The anti-inflammatory
activity of protamine sulphate and of
hexadimethrine bromide, inhibitors of
plasma kinin formation. Brit J Pharmacol
1965; 24: 705-13.
9. Brownlee G: Effect of deoxycortone and
ascorbic acid on formaldehyde induced
arthritis in normal and adrenalectomized
rats. Lancet 1950; 1: 157-159.
10. Satyavati GV, Prasad DN, Das PK and
Singh HD: Anti-inflammatory activity of
Semecarpusanacardium Linn. A preliminary
REFERENCES
Research Article ISSN: 2277-8713
Vipin Kumar, IJPRBS, 2012; Volume 1(5): 193-204 IJPRBS
Available Online At www.ijprbs.com
study. Ind J Physiol Pharmacol 1969; 13:37-
45.
11. Javeed Ahmed Wani, Rajeshwara N
Achur and R K Nema: Phytochemical
screening and aphrodisiac property of
Tinosporacordifolia. International Journal of
Pharmaceutical and Clinical Research 2011;
3:21-26.
12. Singh SS, Pandey SC, Srivastava S, Gupta
VS, Patro B and Ghosh AC: Chemistry and
medicinal properties of Tinosporacordifolia
(Guduchi) Indian J Pharmacol.2003; 35:83-
91
13. Jana U, Chattopadhyay RN and Shw BP:
Preliminary studies on anti-inflammatory
activity of ZingiberofficinaleRosc.,
Vitexnegundo Linn. andTinosporacordifolia
(Willid) Miers in albino rats. Indian J
Pharmacol. 1999; 31:232–3
14. Gulati OD and Pandey DC: Antiinflammatory
activity of
Tinosporacordifolia. Rheumatism. 1982;
17:76–83.
15. Vinegar R, Schreiber W and Hugo RJ:
Biphasic development of carrageenan
edema in rats. J PharmacolExpTher
1969;166:96-103
16. Vagel HG: Analgesic, anti-inflammatory
and antipyretic activity in Drug discovery
and evaluation pharmacological assays, 2nd
Ed. New York: Springer. 2002: 759-67.
17. Prakash Kumar B, Jenny Jacob and Jorny
Augustine: Dual inhibition of
lipoxygenase/cyclooxygenase by an
ayurvedic herb, Tinosporacordifolia
(WILLD.); possible explanation of antiinflammatory
activity. Journal of Pharmacy
Research 2011; 4: 1779-1780.
18. Margolius HS: Tissue Kallikrienes and
kinnins regulation and roles in hypertensive
and diabetic disease. Ann Rev Pharmacol
Toxicol 1989; 29: 343-8.
19. Paul PT, Nathan JZ, Dougulas RG and
Gary FS: Rheumatoid arthritis and p 53:
how oxidative stress might alter the
course of inflammatory diseases.
Immunology today 2000; 21:78-82.
20. Jasbir Singh, AkashBagla and Vikas
Pahal: Hepatoprotective activity of herbal
extracts in carbon tetra chloride intoxicated
albino rats by measuring anti-oxidant
enzymes. International Journal of Pharm
Tech Research. 2010; 2:2112-2115.
Research Article ISSN: 2277-8713
Vipin Kumar, IJPRBS, 2012; Volume 1(5): 193-204 IJPRBS
Available Online At www.ijprbs.com
21. Cotran, Kumar and Collins: Diseases of
immunity. 7th ed. Robbins Pathologic Basis
of Disease. Philadelphia, Pennsylvania.
2005; 252.
22. Leung DY and Bloom JW: Update on
glucocorticoid action and resistance. J.
Allergy Clin. Immunol. 2003; 111: 3–22.
23. Chintalwar G, Jain A, Sipahimalani A,
Banerji A, Sumariwalla P, Ramakrishnan R
and Sainis K: An immunologically active
arabinogalactan from Tinosporacordifolia.
Phytochemistry. 1999;52:1089–93

Thank you for copying data from http://www.arastirmax.com