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URTICA DIOICA L. IN TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
Objective: Study on the efficacy and safety of Urtica dioica L. in the treatment of patients with type 2 diabetes mellitus resistant to conventional oral anti-hyperglycemic drugs requiring insulin. Methodology: In this randomized double-blind placebo-controlled clinical trial, the effects of taking nettle leaf extract (one 500 mg capsule t.i.d. for 3 months) combined with the conventional oral anti-hyperglycemic drugs on the blood levels of fasting glucose, postprandial glucose, glycosylated hemoglobin (HbA1c), lipids, creatinine and liver enzymes including SGOT and SGPT were evaluated in 12 patients and compared with the placebo group (n=10). Results: The extract lowered the blood levels of HbA1c significantly (P=0.03) without any significant effects on the blood levels of fasting glucose, postprandial glucose, lipids, SGOT, SGPT and creatinine (P>0.05) compared with placebo at the endpoint. Further, the blood levels of fasting glucose and HbA1c were decreased significantly in the nettle group compared with baseline at the endpoint (P=0.03 and P=0.01 respectively). However, the blood levels of the other parameters in the nettle group did not change significantly compared with baseline at the endpoint (P>0.05). No adverse effects were reported. Conclusions: The results suggest that nettle may safely improve glycemic control in type 2 diabetic patients.
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  • 5
533-542
  • English

REFERENCES

References: 

1. Philippe J and Raccah D: Treating type 2 diabetes: how safe are current therapeutic agents? Int J Clin Pract 2009; 63 (2): 321-32.
2. Derosa G and Sibilla S: Optimizing combination treatment in the management of type 2 diabetes. Vasc Health Risk Manag 2007; 3 (5): 665-71.
3. Massi-Benedetti M and Orsini-Federici M: Treatment of type 2 diabetes with combined therapy: what are the pros and cons? Diabetes Care 2008; 31 (Suppl 2):
S131-5.
4. Tundis R, Loizzo MR and Menichini F: Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycemic potential in the treatment of diabetes: an update. Mini-Rev Med Chem
2010; 10 (2): 315-31.
5. Fleming T: PDR for Herbal Medicines. Medical Economics Company, New Jersey,
USA, pp 1197-99, 1998.
6. Farzami B, Ahmadvand D, Vardasbi S, Majin FJ and Khaghani SH: Induction of insulin secretion by a component of Urtica
dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozocin diabetic rats. J Ethnopharmacol 2003; 89 (1): 47-53.
7. Rau O, Wurglics M, Dingermann T, Abdel-Tawab M and Schubert-Zsilavecz M: Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor. Pharmazie 2006; 61
(11): 952-6.
8. Onal S, Timur S, Okutucu B and Zihnioglu F: Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem
Biotechnol 2005; 35 (1): 29-36.
9. Simoes-Pires CA, Hmicha B, Marston A and Hostettmann K: A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts. Phytochem Anal 2009; 20 (6): 511-5.
10. Mobasseri M, Bahrami A, Zargami N, Aliasgarzadeh A, Rhmati M and Delazar A: Effect of total extract of Urtica dioica on insulin and C-peptide secretion from rat (RIN5F) pancreatic | cells and glucose
Available Online At www.ijprbs.com
Research Article
Heidari A, IJPRBS, 2012; Volume 1(5):533-542
utilization by human muscle cells. IJE M
2010. 11 (6): 721-7.
11. Chrubasik JE, Roufogalis BD, Wagner H and Chrubasik SA: A comprehensive review on nettle effect and efficacy profiles, Part I: herba urticae. Phytomedicine 2007; 14 (6):
423-35.
12. Fodor JI and Keve T: New phytotherapical opportunity in the prevention and treatment of 2-type of diabetes mellitus. Acta Pharm Hung 2006.
76 (4): 200-7.
13. Said O, Fulder S, Khalil K, Azaizeh H,
Kassis E and Saad B: Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid Based Complement Alternat Med 2008; 5 (4): 421-8.
14. Ozkan G, Sagdic O, Ekici L, Ozturk I and Ozcan MM: Phenolic compounds of Origanum sipyleum L. extract, and its antioxidant and antibacterial activities. J Food Lipids 2007; 14 (2): 157-169.
15. Han J, Weng X and Bi K: Antioxidants from a Chinese medicinal herb -
ISSN: 2277-8713
IJPRBS
Lithospermum erythrorhizon. Food Chem
2008; 106 (1): 2-10.
16. Yoo KM, Lee CH, Lee H, Moon B and Lee CY: Relative antioxidant and cytoprotective activities of common herbs. Food Chem
2008; 106: 929-36.
17. Kim D, Jeong SW and Lee CY. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem 2003; 81 (3): 321-6.
18. The United States Pharmacopoeial Convention. USP 28. Webcom Limited, Toronto, Canada, pp 2094-5, 2005.
19. Prat J, Pamplona R, Sorribas A, Martin S and Segura R: Correlation of plasma lipid fractions with colorimetrically determined glycated hemoglobin in a nondiabetic population. Metabolism 1989. 38 (12): 1147-53.
20. Rahimi R, Nikfar S, Larijani B and Abdollahi M: A review on the role of antioxidants in the management of diabetes and its complications. Biomed
Pharmacother 2005; 59 (7): 365-73.

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