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COMPARISON OF THE ANALGESIC EFFICACY AND SAFETY OF PRE & POST OPERATIVE ORAL KETOROLAC FOR DENTAL EXTRACTION PAIN

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Objective: To compare the analgesic efficacy and safety of the single-dose oral ketorolac pre & post operatively for dental extraction pain. Materials and Methods: 49 Patients who were undergoing third molar extraction (impacted or other causes) were recruited into the study, over a period of one year. The patients were divided into four groups to receive ketorolac (20 mg) or placebo either preoperatively or postoperatively (half - an - hour before or half - an - hour after the procedure). Pain assessment was done using a modified Verbal Rating Scale (VRS), at 30 minutes, 2 hours, 4 hours and 6 hours after the procedure. A record of whether rescue analgesic (ibuprofen 400 mg) was taken during the 6 hours study period, along with the time it was taken, was made. Record of any adverse effects experienced by the patient was also kept. Maximum pain scores for each of the 4 study groups, over the 6 hours study period. Secondary end points are time when rescue analgesic was taken, adverse effects observed. Results: Ketorolac was significantly better than placebo, in relieving molar tooth extraction pain. Preoperative administration of Ketorolac was found to be more efficacious than postoperative administration in relieving the pain. Conclusion: This study demonstrated that Ketorolac, a NSAID's is effective in relieving pain in the first 6 hours after molar extraction and therefore can be tried in patients who are undergoing molar extraction.
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  • 6
260-271
  • English

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