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PRONIOSOMES - A SURROGATE FOR TRANSDERMAL DRUG DELIVERY

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery, diagnostics, nutraceuticals and biomedical for implants and prosthesis. The advance in nanotechnology helps in preparing newer formulations. Controlled release drug products are often formulated to permit the establishment and maintenance of drug concentration at target site for longer interval of time. One such technique of drug targeting is 'niosome'. In order to minimize the problems associated with niosome physical stability such as aggregation, fusion and leaking and to provide additional convenience in transportation, distribution, storage and dosing etc. a dry product can be prepared from niosome called proniosome. In all comparisons, proniosomes are as good as or better than conventional niosome. One of the advancement in nanotechnology is the preparation of proniosomes - derived niosomes. Proniosomes are solid colloidal particles which may be hydrated immediately before use to yield aqueous niosome dispersions similar to those produced by more cumbersome conventional methods. These 'proniosomes' minimize problems of niosome physical stability such as aggregation, fusion and leaking, and provide additional convenience in transportation, distribution, storage, and dosing. This article describes the preparation of dispersions of proniosome-derived niosomes; In addition proniosome-derived niosomes are described in terms of their morphology, particle size, particle size distribution, and drug release. In all parameters proniosome-derived niosomes are as good as or better than conventional niosomes.
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  • 6
10-26
  • English

REFERENCES

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