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PRUNUS DOMESTICA PROTECTS AGAINST HEPATIC AND INTESTINAL DAMAGE INDUCED BY RADIATION IN SWISS ALBINO MICE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

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Author Name
Abstract (2. Language): 
The present study focused on the possible protective effect of Prunus domestica extract (PDE) against radiation induced damage in liver and small intestine of Swiss albino mice. Male mice were distributed into five groups of 10 mice each. Prunus domestica fruits extract (PDE) was evaluated for in vivo radio protective activity against whole body gamma irradiation in Swiss albino mice. Radiation induced histological lesions and antioxidant parameters were observed. PDE was found to have strong radical scavenging activity in 2, 2- diphenyl-1-picrylhydrazyl (DPPH*). PDE supplementation augmented the antioxidant defence indices, such as reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) lowered by radiation exposure. Histopathological observations revealed damage in irradiated animals which were found to be reduced by supplementation of PDE prior/post irradiation. These findings suggest the possible radio protective role of antioxidants present in PDE in ameliorating hepatic and intestinal injury via free radical scavenging mechanism.
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  • 6
153-165
  • English

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Available Online At www.ijprbs.com
Research Article
Rashmi Sisodia, IJPRBS, 2012; Volume 1(6): 153-165
ISSN: 2277-8713
IJPRBS
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