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A NOVEL CONCEPT FOR ENHANCEMENT OF SOLUBILIZATION AND BIOAVAILABILITY OF POORLY SOLUBLE DRUGS: HYDROTROPY: A REVIEW

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilizing agents, modification of the crystal habit, co-crystallization, complexation and drug dispersion in carriers. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics. Hydrotropy is a solubilization phenomenon whereby addition of large amounts of a second solute results in an increase in the aqueous solubility of another solute. A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solution. To solubilize water insoluble drugs especially in case of oral formulation, solubility remains a critical factor so for in this review various solubility enhancement techniques are highlighted and a brief review of hydrotropy and its preparation are discussed.
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  • 1
372-381
  • English

REFERENCES

References: 

1. http://www.pharmatutor.org/articles/dif ferent-methods-enhancement-solubilization-bioavailability-poorly-soluble-drugs-review
2. USP-NF: The Official Compendia of Standards. Reference Table/Description and
Solubility, USP 29; 2006: 3191.
3. http://ijppronline.in/index.php?option=c om_content&view=article&id=185&Itemid=
155
4. Gaikar VG: Hydrotropic properties of sodium salts of ibuprofen. Drug Dev Ind
Pharm 1997; 23: 309-312.
5. Kennth CJ: Aqueous solubilities, In: Kennth CJ, (Ed.), Solubility & Related Properties, 1986, Published by Informa health care, Inc., New York, 355.
6. Kapadiya N, Singhvi I, Mehta K, Karwani G and Dhrubo JS: Hydrotropy: A Promising
Tool for Solubility Enhancement: A review. International Journal of Drug Development
& Research 2011; 3(2): 26-33.
7. Jain P, Goel A, Sharma S and Parmar M: Solubility Enhancement Techniques with Special Emphasis on Hydrotrophy. International Journal of Pharma Professional's Research 2010; 1(1): 34-45.
8. Maheshwari RK, Deswal S, Aher R, Wanare G, Jawade S, Indurkhya A and Jagwani Y: Ibuprofen Sodium: A Novel Hydrotropic Agent For Estimation of Poorly Water-Soluble Drugs. Journal of Applied Chemical Research 2009; 10: 56-60.
9. Maheshwari RK, Deswal S, Tiwari D, Ali N, Pothen B and Jain S: Novel spectrophotometric estimation of frusemide using hydrotropic solubilization phenomenon. Indian Journal Pharmaceutical Science 2007; 69(6): 822¬824.
10. Maheshwari RK, Chavada V, Varghese S and Shahoo K: Analysis of bulk sample of salicylic acid by application of hydrotropic solubilization method. Indian journal pharmaceutical science 2008; 70(6): 823¬825.
Available Online At www.ijprbs.com
Review Article
Satyanand Tyagi, IJPRBS,
2013; Volume 2(1): 372-381
11. Sharma R, Pathodiya G and Mishra PG: A novel application of hydrotropic solubilization in development and validation of spectrophotometric method for simultaneous estimation of paracetamol and diclofenac sodium in solid dosage form International Journal of Pharma and Bio
Sciences 2010; 1(3): 1-9.
12. Maheshwari RK, Deswal S, Aher R, Wanare G, Jawade S, Indurkhya A and Jagwani Y: Ibuprofen Sodium: A Novel Hydrotropic Agent For Estimation of Poorly Water-Soluble Drugs. Journal of Applied Chemical Research 2009; 10: 56-60.
ISSN: 2277-8713 IJPRBS
13. More HN and Hajare AA: Practical physical pharmacy. Career publication,
2010: 230.
14. Bhole PG and Patil VR: Enhancement of water solubility of felodipine by preparing solid dispersion using poly-ethylene glycol 6000 and poly-vinyl alcohol. Asian journal of pharmaceutics 2009; 3(3): 240-244.
15. Maheshwari RK, Chaturvedi SC and Jain NK: Novel application of hydrotropic solubilization in the analysis of some NSAIDs and their solid dosage forms. Indian Journal of Pharmaceutical Sciences 2007;
69(1):101-106.

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