DESIGN, DEVELOPMENT AND EVALUATION OF ANTIDIABETIC LIQUID ORAL PREPARATION FROM EXTRACT OF FENUGREEK

Present investigation is aimed at development of suitable liquid oral dosage form from ethanolic extract of fenugreek {Trigonella foenum-graecum). Fenugreek seeds were extracted by soxhlation method using ethanol as solvent. Ethanolic extracts were subjected to preliminary phytochemical screening to detect the presence of various active constituents. Extracts were evaluated for invitro- antidiabetic activity by determining alpha-amylase inhibitory activity. Based on the alpha-amylase inhibitory activity, amount of fenugreek extracts were chosen for formulation of liquid orals. Three different liquid oral formulations have been prepared from ethanolic extracts of fenugreek using various vehicles such as glycerin, hydro alcohol and propylene glycol. All the prepared formulations were evaluated for measurement of pH, specific gravity & stability in order to select the best liquid oral of fenugreek. Among three Liquid oral formulations glycerin based liquid oral formulation of fenugreek showed good elegance, more palatability due to higher viscosity with pH in which extracts remains stable. Results of stability study of all the liquid oral formulations indicate good stability without turbidity at storage temperature.