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EFFECT OF APPLICATION OF SOLUBILIZERS SUCH AS PVP K 30,PEG 400 AND TWEEN 80 ON THE ENHANCEMENTOFSOLUBILITY OF IBUPROFEN BY FACTORIAL DESIGN

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Abstract (2. Language): 
The present study is to evaluate the application of solubilizers such as PVP K 30,PEG 400 and Tween 80 for enhancing the solubility of Ibuprofen, a BCS class II drug.The individual and combined effects of PEG 400, PVP K 30 and Tween 80 on the solubility were evaluated in a 23 fractional study.In the 23 fractional study the three factors namely PEG 400(factor A), PVP K 30 (factor B) and Tween 80 (factor C), each at the two levels (0 and 2% concentration),were investigated for the individual and combined effects on the solubility of Ibuprofen. The results of solubility were analyzed as per analysis of variance (ANNOVA) of 23 factorial designs to find out the individual and combined effects of the three factors involved.
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