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A NEW KINETIC SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFIXIME IN PHARMACEUTICAL PREPARATIONS USING SAFFRON EXTRACT AS NATURAL REAGENT

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Abstract (2. Language): 
A new simple and sensitive kinetic spectrophotometric method has been proposed for the determination of cefixime in pure form and pharmaceutical formulations. The proposed method is based on the formation of yellow coloured product (λmax = 390nm) that resulted after addition of the mixture, which is composed of saffron extract, sodium hydroxide and potassium permanganate, to cefixime aqueous solution. The experimental conditions have been optimized. Beer’s law is obeyed over the concentrations of 10-0.6μg/ml, with a linear regression correlation coefficient of 0.994. The proposed method has been successfully applied in the determination of cefixime in pharmaceutical dosage forms.
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