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CORRELATION BETWEEN SERUM AMINOTRANFERASE LEVELS AND HCV RNA LOAD IN HEPATITIS C VIRUS RELATED CHRONIC LIVER DISEASE.

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Background: Hepatitis C virus (HCV) is a common infection that can lead to end stage liver disease in India. Viral load in chronic hepatitis is considered a strong predictor for the disease progression, it is unclear whether there is any link between the increasing viral loads with the other circulating biomarkers. Aim & Objectives: The aim of this study was to investigate the relationship between serum HCV RNA titre and serum aminotranferase levels in patients with HCV related chronic liver disease. Methods: A total of 33 patients with HCV related chronic liver disease were included in the study. Anti HCV antibodies were determined either by rapid card test (TRIDOT) or by IIIrd generation ELISA. Serum alanine aminotranferase (ALT)/ aspartate aminotranferase (AST) levels were measured by an automatic biochemical analyzer. The COBAS®TaqMan®HCV test, v 2.0, an in-vitro nucleic acid amplification test was used for the quantitation of HCV RNA in the patient’s serum. The correlation between ALT/AST levels and HCV RNA titre were analyzed by calculating Spearman rank correlation coefficient and p<0.05 was considered significant. Results: An average value of ALT was found to be 64.15 IU/ml with a standard deviation of 65.03 (Range 16-370 IU/ml) and that of AST was 69.0 IU/ml with a standard deviation of 60.8 (Range 17-315 IU/ml). Average HCV RNA titre was evaluated as 10.5x106 IU/ml (Range 8.83x102 - 9.8x107 IU/ml). A statistically significant positive correlation was observed between serum ALT levels and HCV RNA titre, however the positive correlation observed between HCV RNA titre and serum AST levels was not statistically significant. Conclusion: A positive correlation was observed between HCV RNA titre and the serum aminotranferase levels in patients with chronic liver disease. In addition to viral load, HCV genotype and histological damage has to be determined to assess the degree of liver damage, though decreasing viral load in response to therapy has a prognostic value.
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