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TENOKSİKAMIN SIÇANLARDA OLUŞTURULAN DENEYSEL AĞRI MODELİ ÜZERİNE ETKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Tne mechanism involved in the anaîgesic activity of nonsteroidal anliinflammalory drugs (NSAİDs) have been considered by prostaglandins and other vasoactivc substrates synthesis arter celi injury. It is claimed that NSAİDs have anaîgesic cffect by other central and peripheral mechanisms other than tissue injury. The aim of this sludy was to evaîuate the effcct of tenoxicam, as NSAİD, on the thres-hold of the cxperimental pain due to heat, and to investigate the effecl on the pain model wit-hout inflammation. Ten Wistar-Albİno rats were assigned to two groups, each of which was made up of five rats. 3 mg/kg tenoxİcam was administered to study group, and placebo the control group. After 2 hours, tails of the rats heated by halogen Hght using analgesimeter. Rc-action time to pain was measured by tail-flick method. Pain tolerance time to heat was sİgnifi-cantly longer in the tenoxicam group than controls (respcctively, 14+9.13 sec, 5.5+1.29 sec, p<0.05). These results had shown thet tenoxicam inereased tolerance time to pain sccondary to heat vvithout tissue injury. It is considered that tenoxicam has central or peripheral blockİng ef-fect of pain conduetion.
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Abstract (Original Language): 
Nonsteroid antiinflamatuvar ilaçların {NSAİİ) analjezik etkileri hücre yıkımı ardından oluşan prostaglandİn ve benzeri algojenik vazoaktİf maddelerin inhibisyonu ile açıklanmaya çalışır Oysa NSAİİ' nin doku yıkımı olmadan oluşan ağrıyı başka santral ve peıifcrik mekanizmalarla da inhibe edebileceği ileri sürülmektedir. Bu düşünceden yola çıkılarak, bir NSAİİ olan le-noksikamın sıçanlarda ısı ile oluşturulan deneysel ağrı eşiğine olan etkisini ölçmek ve infla-masyonun devreye girmediği potansiyel ağrı modelinde etkisini araştırmak amaçlandı. On adet Wistar-Albino sıçan çalışmaya alınarak iki gruba ayrıldı, 5 tanesine nazogastrik tüp İle 3 mg/kg dozda tenoksikam, diğer 5' ine ise plasebo verildi. İki saat sonra ışık ile oluşturulan ısı kaynağı kullanılarak "tail-flick" yöntemi ile ağrıya reaksiyon süresi ölçüldü. Tenoksikam verilen sıçanlarda ısıya dayanma süresi kontrol grubundaki sıçanlardan daha uzun olup aralarındaki fark istatistisel olarak anlamlı idi (sırası İle, 14±9,13 saniye, 5.5+1.29 saniye, p<0.05). Sonuçlar tenoksikamm doku harabiyeti gelişmeden ısıyla oluşturulan ağrıya direnci arttırdığını göstermektedir. Tenoksikamm periferden veya santral yollarla ağrı iletimini engelleyebilme özelliği taşıdığı düşünülmektedir.
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  • 3
264-267
  • Turkish

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