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OSTEOPOROZDA AİLE ÖYKÜSÜ VE CİNSİYET FAKTÖRÜNÜN İNCELENMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Family history and gender effect in osteoporosis. There is a lot of epidemi ol ogical evidence supporting the role for genetic İnfluences on the bone density and osteoporotic fraetures. İn this study, the family history of osteoporosis and its interaction with enviromental conditions have been evaluated. A qucstionnaire form was prepared and filled out for each 92-male and 298-female research subject after his or her Dual Energy X-ray Absorbsiometry (DEXA) had been performed. The anthropometric data, education level, menopausc age, skin and hair color, diabetic habit, and the resideney area of the subjects were recorded. İn addition, the inforınation about the previo-us fraetures and osteoporosis İn their families were obtained. In this study, the subjects belonging to osteoporotic and control groups differed from each ot-her with respect to some characteristics such as age, body mass index, education, menopouse age and resideney. We have found that previous fraetures do not play an important role in the determination of osteoporosis. The inquisition of osteoporosis or relevant factors İn a family has had no predietive power on the osteoporosis in female subjects wheıeas osteoporosis has been more frequently diagnosed in male subjects having a positive fraeture history in their fa-milİcs. As a conelusion, it İs crucial for the predietion of osteoporosis that males be questioned in terms of the family history in clinical praetice in addition to the enviromental conditions with which they are faced. Hcncc, for those patients who are subject to furlher complicated exposi-tions will be seleeted based on more accurate criteria.
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Abstract (Original Language): 
Kemik mineral yoğuniuğu (KMY) ve osteoporotik kırıklar üzerinde genetik faktörlerin rolünü destekleyen pek çok epidemiyolojik kanıt bulunmaktadır. Bu çalışmada osteoporozda aile hikayesi ve bunun çevresel faktörlerle etkileşimi araştırılmıştır. Bu amaçla Dual enerji X-ray absorbsİometre (DEXA) ölçümleri yapılmış 92 erkek ve 298 kadın için bir sorgulama formu doldurulmuştur. Antropometrik veriler, eğitim düzeyi, menopoz yaşı, cilt ve saç rengi, diyel ve yerleşim yeri kaydedilmiştir. Ayrıca önceki kırıklar ve ailede osteoporoz hikayesi ile ilgili bilgi edinilmiştir. Çalışmamızda osteoporozu olanlar ile kontrol grubunda yer alan olgular yaş, vücut kitle indeksi, eğitim durumları, menopoz yaşı ve yerleşim yerleri gibi özellikleri yönünden farklılık göstermekteydiler. Önceki geçirilen kırıkların osteoporozu belirlemede önemli olmadığı bulunmuştur. Ailede osteoporoz veya ilişkili faktörlerin sorgulanması, kadın olgularda osteoporozu olanları tahmin etmede önemli bulunmamış tır. Ailelerinde kırık öyküsü olan erkeklerde ise osteoporoz daha sık olarak gözlenmiştir. Sonuç olarak osteoporozun kestİrimi için klinik pratikte, çevresel faktörlerin yanısıra aile öy-küsüün sorgulanması erkek bireyler için önem taşımaktadır. Böylece ileri tetkik uygulanacak olan hastalar daha doğrulukla belirlenecektir.
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  • 1
68-75
  • Turkish

REFERENCES

References: 

1. Baran DT: Magnitude and determinants of premenopau-sal boneloss, Ostcoporos Int 1:31 (1994).
2. Bardıe N, Bassc-Cathaiinat B, Meunier PJ, Riboi C, Marchandise X, Sabaü'er JP, Braillon P, Thevenot J, Sut-tcr B: Measurement of bone mineral dcnsity in nıothcr-daughtcr pairs for evaluating the family influence on bone mass acquisition: a GRIO survey, Osteoporoz Int 8:379 (1998).
3. Başaran N: Tıbbi Genelik Bilim Teknik Yayınevi, Eskişehir, 6. Baskı (1996).
4. Bauer DC, Browncr WS, Cauley JA, OrwoIl ES, Scot! JC, Black DM, Tao JL, Cummings SR: Factors assocİa-tcd wifh appendicular bone mass in older women. The Study of Osteoporotic Fraetures Research Group. Ann lnlcm Med 118:657 (1993).
5. Cohen-Solal ME, Baudoin C, Omouri M, Kuntz D, De Vernejoul MC: Bone mass in middle-aged osteoporotic men and their relatives: familial effect, J Bone Miner Res 13:1909 (1998).
6. Cummings SR, Nevitt MC, Browner MS, Sloııe K, Fox M, Ensrud KE, Cauley J, Black D, VogtTM: Risk factor for hip fraeture in white women. N Engl .1 Med 332:767 (1995).
7. Cumming RG, Cummings SR, Nevitt MC, Scoll JJ, Ensrud KE, Vogt TM, Fox K: Calcium intake and fraeture risk: resuüs from the study of osteoporotic fraetures. Anı J Epidemiol 145:926 (1997).
8. Danielson ME, Cauley JA, Baker CE, Newman AB, Dormal JS, Towers JD, Kullar LH:Faıniliat rescmblance of bone mineral density (BMD) and calcaneal ulirasound attenuation: the BMD in mothers and daughters study, J Bone Miner Res 14:102 (1999).
9. Dilşcn G: Osteoporozda oluşan kırıkların epidcmiyoloji-si. Aktüel Tıp Dergisi 2:460 (1997).
10. Fleming KH, Heimbach JT: Consumption of calcium in the U.S.: food soıırces and intake levels. J Nutr 124:1426S (1994).
11. Friedmen JM, Hayden MR, McGilivray BA: Genetik (çeviri), Saray Medikal Yayıncılık, İzmir, 1. Baskı (1995).
12. Frosi H: On our age-rclatetl bone loss: İnsights from a ncw paracligm, JBone MinRes 12:1539 (1997).
13. Gounding A, Gold E, Wa1kcr R, Lewis-Barned N: Wo-ınen with pasl history of bone fraetures have low spinal bone density before menopause. N Z Med J 110:232 (1997).
Kavuncu H., Elyas H., Akın H., Kavuncu V.
14. Gökmen A, Seçkin Ü, Bodur H, Yücel M, Pekcan G, Akçıl M, Koksal E, Bostan S: Osteoporozda risk faktörleri, Osteoporoz Dünyasından, 4:525 (1998).
15. Gunnes M, Mellstrom D, Johnel O: How well can a pre-vious fraeture indicate a new fraeture? A qucstionnaire study of 29802 poslmcnoposual women. Açta Orthop Scand695Û8 (1998).
16. Hanscn MA, Hassager C, Jensen SB, Christiansen C: Is herilabilily a risk factor for poslmcnoposual osleoporo-sis? J Bone Miner Res 7:1037 (1992).
17. Heaney RP: Nutrutional factors in osteoporosis. Arınu Rev Nutr 13:287 (1993).
18. Johanson C, Melislrom D: An eaılier fraeture as a risk factor for ne\v fraeture and its association with smoking and menopausal age in women, Malurilas 24:97 (1996).
19. Johnel O, Gullberg B, Kaniş J, Allender E, Elffoıs L, De-queker J, Dilsen G, Gennori C. Lopes Vaz A: Risk factors for hip fraeture in European Women: The Medos Study, J Bone Miner Res 10:1802 (1995).
20. Kaniş JA, Passmone R: Calcium supplementation of the diet-I and II. Br Med J (1989), 298:137,205:8.
21. Kannus P, Jarvincn M, Sievanen II, Oja P, Vuoı i I: Osle-oporosis in men with a history of tibial fraeture, J Bone Miner Res 9:423(1994),
22. Karamehmetoğlu SŞ, Eryavuz M, Majlesi J, Karacan İ, Çalış M, Akyddız H: Ostcoporoza bağlı kırık geçiren hastalarda risk faktörlerinin değerlendirilmesi. Osteoporoz Dünyasından 1:17 (1996).
23. Kavuncu V, Şahin S, Kamanh A, Boz K, Ardrçoğiu O: Osteoporotik vertebra veya kalça kırığı geçiren hastalarda risk faktörlerinin değerlendirilmesi, Fırat Tıp Dergisi 6:384(1988).
24. Keen RW, Kelly QJ: Genctic factors in osteoporosis. What are the implications for prevention and treatment? Drugs Aging 11:333 (1997).
25. Keleş R, Eryavuz M, Akaırmak Ü, Karacan İ, Önel D: Vücut kitle indeksi ile kemik mineral yoğunluğu arasındaki ilişki, Osteoporoz Dünyasından 4:393 (1997).
26. Kelly PJ, Nguyen T, Pocock N, Hopper J, Sambrook PN, Eisman Ja: Genetic determination of changes in bone density with age: a twin study. J Bone Mİner Res 8:11 (1993).
27. Kung AW, Luk KD, Chu LW, Clıiu PK: Age-related osteoporosis in Chintıese: an evaluatton of Ihe response of intestinal calcium absorption and calcilropic hormones to dietary calcium deprivation. Anı J Clin Nutr 68:1291 (1998).
28. May H, Murphy S, Khaw KT: Bone mineral density and ils relationship lo skin colour in Caucasİan females, Eur J Clin invest 25:8,5 (1995).
29. O'Brien KO, Abrams SA, Liang LK, Ellis KJ, Gagcl RF: Bone turnover response to changes in calcium intake is aitered in girls and adult women in families with histori-es of osteoporosis. J Bone Miner Res 13:491 (1998).
30. Perez CR, Galan GF, Düsen G: Risk factors for hip frac-lure in Spanish and Turkish womeıı. Bone 1:S69 (1993).
31. Sccman E, Tsalamandaris C, Formica C, Fonıtica C, Hopper JL, McKay J: Reduced femoral neck bone density in the daughters of women with hip fraetures: The role of low bone density in the patbogenesis of osteoporosis. J Bone Miner Res 9:739 (1994).
32. Seemcn E, Hooper JL, Bbach LA, Cooper ME, Parkin-son E, McKay J, Jerums G: Reduced bone mass in daughters of womcn with osteoporosis. N Engl J Med 320:554(1989).
33. Slovik DM, Adams JS, Neer RM, Holick MF, Potls JT: Deficient produetion of 1,25 dihydroxyvitamin D in el-derly osteoporotic patients, N Engl J Med 305:372 (1981).
34. Soroko SB, Barrett-Connor E, Ede.stein SL, Kritz-Sil-verstein D: Family history of osteoporosis and bone mineral density at the axial skeleton: the Rancho Bernaıdo study J Bone Miner Res 9:761 (1994).
35. Sowcrs M: Clinical epidemiology and osteoporosis. Me-asures and their interpretation, Endocrinol Mctabol Clin North Anı 26:219 (1997).
36. Sowers MR, Bunıs TL, Wallacc RB: Familial resembian-ce of honc mass in adult womctı, Genet Epidemiol 3:85 (1986).
37. Villarel AR, Villareai DT, Avioli LV, Civitelli R: Estro-gen status and heredity are majör determinalions of pre-menopausal bone mass. J Clin invest 90:2462 (1992),
38. Wark JD: Osteoporotic fraetures: background and prevention strategies, Maturİtas 23; 193 (1996).
39. VVeinstein RS, Bell NH: Dîminished rates of bone forma-tion in normal black adults. N Engl J Med 319:1698 (1998).
40. WHO: Assessmenl of osteoporotic fraeture risk and its role in scıeening for postmenopausal osteoporosis. WHO Technicu] Rcport. Series, Geneva (1994).
41. Yeap SS, Bcaumont M, Bennelt A, Kcating NA, White DA, Hosking DJ: Genetic and environmental factors af-feeting bone mineral density in large families. Postgıad Med J 74:349 (1998).

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