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ŞİŞMAN KADINLARDA DİABETES MELLİTUS VE BOZULMUŞ AÇLIK GLİKOZU SIKLIĞI VE METABOLİK RİSK GÖSTERGELERİ İLE İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Diabetes mellitus and impaired fasting glucose in obese women and its relationship with cardiovascular risk factors. The aitn of this study is to examine the incidence of impaired fasting glucose and diabetes mellitus and its relationship with metabolİc risk markers in obese women. Study group is consİsted of 1436 obese (body mass index, BMI>27kg/m2) vvomeıı, Subjects with a history of diabetes mellitus were excluded. impaired fasting glucose was defi-ned by fasting blood glucose (FBG) >110-126 mg/dL (n: 182, 13%) and diabetes mellitus was del'İned by FBG>126 mg/dL (n: 91, 6%). Total eholesterol, triglyceride, uric acid, insulin (İog), HOMA, fructosamine, systolic and diastolic blood pressure, weight, BMI, waist circum-ference and waisthip ratio were to be significantiy different bctween these groups. Risk markers levels were significantly higher in diabetes mellitus group than other subjects. Tbese rc-sults suggested that weİght cxccss, cspcciaJly with abdominal fat distribution would result in abnormal glucose tolerance in obese women. These findings implies a particular care for a sereening of impaired glucose tolerance in obese women.
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Abstract (Original Language): 
Bu çalışma şişman kadınlarda bozulmuş açlık glikozu ve diabetes mcllitus sıklığını ve melabo-lik risk göstergeleri üe ilişkisini araştırmak amacıyla gerçekleştirildi. Çalışma kapsamına diabetes mcUitus anamnezi bulunmayan [436 şişman (vücut kitle indeksi, BMI>27kg/mz) kadın hasta alındı (yaş sınırlan 19-81 yıl). Açlık glikoz değerinin 110 mg/dL in altnıda olması normal glikoz toleransı (n: 1163, %81), 110-126 mg/dL olması bozulmuş açlık glikozu (n: 182, %13) ve 126 mg/dL in üzerinde bulunması diabetes mellitus (n: 91, %6) olarak kabul edildi. Üç grup arasında total kolesterol, trigliserid, ürik asit, insülin (İog), HOMA, früktozamin, sis-tolik ve diyastolik damar basmcı, ağırlık, BMI, bel çevresi ve bel/kalça oram bakımından anlamlı farklılık mevcuttu. Risk göstergesi düzeyleri diabetes mellitus>bozulmuş açlık glİko-zu>normal glikoz toleransı grupları olarak sıralandı. Şişman kadınlarda kilo fazlalığı ile birlikte olan abdominal yağ toplanmasının glikoz toleransında bozulmaya yol açtığı düşünüldü. Bunun yamsıra, glikoz İntoleransı arttıkça risk göstergelerinin de yükseldiği saptandı. Bu meîa-bolik sendrom varlığı olarak yorumlandı. Bulgular, şişman kadınların glikoz intoleransı açısından özellikle izlenmesi gerektiğini düşündürmektedir.
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  • 1
19-23
  • Turkish

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