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APLASTIK ANEMILI 20 VAKANIN ÇEVRE KANI MONOSIT VE GRANÜLOSİTLERİNDE CD 55 VE CD 59 TAYİNİ VE BUNLARIN KLİNİK SEYİRLE İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The value ofthe assessmem ofCD 55 and CD 59 in the peripheral blood monoeytes and gra-nulocyt.es inpatients wiîh aplastic anemia: A study İn 20 cases. Peripheral blood monoeytes and granulocytcs of 14 healthy persons and 12 cases of severe and 8 cases of very severe aplastic anemia were investigated with flow cytomelry for CD 55 and CD 59 expressioııs. Ham and sugar-water tests vvere also performed in thc patient group. The patients could be divided into two subgroups according to the level of cxpression of CD 55 and CD 59. Thus, in 9 patients the expression of CD 55 and CD 59 were within normal limits whereas in 11 patients the-re expressions were less than the lower limits of normal values. In none of the twenty patients, the Ham and the sugar-water tests were found positive during thc mean follow up period of 22 months (range 3-57 mo). It has been observcd that responses of the patients to treatment (an-tilymphocyter globulin, cyclosporine A, granulocyte colony stimulating factor, methylprcdni-solone) vvere parallel to their values of expressions namely rhose vvith lovv CD 55 and CD 59 expressions responded poorly to the immunsuppressive treatment than those vvith normal values.
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Abstract (Original Language): 
Sağlıklı 14 şahısta ve 8'i çok ağır, 12'si ağır aplastik anemili vakalarda tedaviye başlamadan evvel çevre kanı monosit vc granülositlerinde "flow" sitometreyle CD 55 ve CD 59 ifadelen incelendi. Bunlara ilaveten hasta grubuna kronik hemoliz testlerinden Hanı ve şeker-su testi yapıldı. Hastalar, herbir hastada çevre kanı monosit ve granülositlerinde tespit edilen CD 55 ve CD 59 ifadelerinin normal gruptaki herhangi bir değerin minimumundan küçük oluşuna, göre iki gruba ayrıldı. Böylece 9 hasta CD 55 ve CD 59 ifadeleri normal sınırlarda ve 11 hastada ise bunların ifadeleri normalden düşük olarak tespit edildi. Yirmi hastanın hiçbirinde takip edildikleri ortalama 22 (3-57) ay içinde Ham ve şeker-su testleri pozitif bulunmadı. Anti-lenfositer globulin, siklosporm A, granülosk koloni uyarıcı faktör ve metil prednizolondan oluşan yoğun immunsupressif tedaviye CD 55 ve CD 59 ifadeleri düşük olan hastalarm cevaplarının normal bulunanlardan kötü olduğu tespit edildi.
FULL TEXT (PDF): 
PDF icon arastirmax-aplastik-anemili-20-vakanin-cevre-kani-monosit-granulositlerinde-cd-55-cd-59-tayini-bunlarin-klinik-seyirle-iliskisi.pdf
  • 2
123-127
  • Turkish

REFERENCES

References: 

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