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SİROZLU HASTALARDA ANTIKARDIYOLIPIN ANTİKORLARI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Anticardiolipin Antibodies in the Patients with Liver Cirrhosis. Antieardiolipin antibodies (ACA) have becn reported in numcrcous conditions apart from primary antihospholipid syndrome. In this study, we searehed presence of ACA in 25 cirrhotic patients. ACA levels of cİrrhotİc patients wcrc significantly highcr than controls. Number of thc patients who have high ACA IgG and IgM levels (at least +2 SD) were higher than controls. Tlıerc was no corre-lation betvvccn ACA levels and Child stages of thc ciırhoüc patients. We foutıd a poskive cor-relalion betwecn ACA and gammaglobulin levels. In conelusion, ACA levels have becn inere -ased in chxhotic patients, but this seems not to be related with stage and complİcations of cirrhosis. High ACA levels might be refleeting hypergammaglobulinemia seen in cirrhotic patients.
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Abstract (Original Language): 
Antifosfolipid antikorları anüfosfolipid scndromuııun yamsıra, birçok hastalıkta yüksek bulunabilmektedir. Bu çalışmada karaciğer sirozlu 25 hastada antikardiyolîpin antikorlarının (AKA) varlığı vc kJinik ve biyoşimik parametrelerle ilişkisi araştırıldı. Hastaların ortalama AKA Ig G ve Ig M düzeyleri kontrol grubuna göre yüksek bulundu. AKA IgG ve IgM düzeyleri en az +2 standart sapma artmış olan hasta sayısı da kontrol grubuna göre daha fazla idi. AKA düzeyleri sirozun evresi ile ilişkili değildi. AKA düzeyleri gamma globulin düzeyleri ile pozitif korelasyon göstermekteydi. Sonuç olarak, sirozlu hastalarımızda AKA düzeyleri yükselmektedir ve bu yükseklik hastalığın evresi ve komplikasyonlan ile ilişkisiz gibi görünmektedir. AKA düzeylerindaki yükseklik sirozlu hastalarda görülen genel gammaglobulin artışının bir yansıması olabilir.
FULL TEXT (PDF): 
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  • 2
142-146
  • Turkish

REFERENCES

References: 

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