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DEĞİŞİK YAŞLARDA TANILARI KONULAN KONJENITAL PRIMER HİPOTİROİDİLİ ÇOCUKLARIN TEDAVİ İLE BÜYÜMELERİNİN DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Growth Of Children With Primary Hypothyroidism On Treatment With Respect To Different Ages At Diagnosis. The grovvth data of 137 (90F.47M) children with congenital primary hypothyroidism (CPH) diagnosed prior to neonatal screening pıogramme and followed for a mean duration of 8.7±4.4 years (2.3 -18.2) were analyzed retrospectively. CPH was due to thyroid aplasia in 43.8%, dyshormonogenesis in 31.4%, hypoplasia in 19.7% and ectopy in 5.1%. The children were divided with respect to age at diagnosis into Group 1 (30.6%) diagnosed betvveen 0-3 months, Group 2 (38.8%) betvveen 3-12 months and Group 3 (30.6%) bet-ween 1 and 5 years of age. Group 1 had a significant better height Standard deviation score (SDS) at the latest visit (0.6 ± 0.5) than 2 (-0.4 ± 0.9) and 3 (-1.2 ± 1.0). There was an inverse correlation betvveen height SDS and time passed for normalization of serum TSH(r:- 0.51) and bone age delay (r:-0.68) and a positive correlation with serum T4 levels (r:0.59)(p<0.001). Body mass index SDS, although higher in general in ali children, was significantly lower in Group 1 (- 0.4+ 0.6) than in Group 3 (1.1+ 0.6). Puberty started at normal age in girls (n:30) (10.9±1.4 yrs) Hovvever, it was rather shorter. In conclusion, early and optimum treatment re-sults in an appropriate height. T4 and TSH levels and bone age reading are useful parameters for the follow-up of grovvth in hypothyroidism.
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Abstract (Original Language): 
Kliniğimizde neonatal tarama programı uygulamaya başlamadan önce, farklı yaşlarda tanıları konulan konjenital primer hipotiroidili (KPH) 137 çocuğun (90K, 47E) büyüme verilen 8.7+4.4 yıllık bir izlem süresinde retrospektif değerlendirildi. Etiyoloji %43.8 aplazi, %31.4 dishormonogenez, %19.7 hipoplazi, %5.1 ektopi idi. Hastalar Grup 1: 0-3 ay (%30.6), Grup 2: 3-12 ay (%38.8), Grup 3: 1-5 yaş arası (% 30.6) tanı konanlar olarak 3 gruba ayrıldı. Son muayenede Grup l'in boy standart sapma (SDS) değeri (0.6 ± 0.5), Grup 2 (-0.4 ± 0.9) ve Grup 3'den (-1.2 ± 1.0) daha yüksek idi. Boy SDS ve tedavi sırasında TSH normalleşme süresi (r:-0.51) ve kemik yaşının (KY) geriliği (r:-0.68) arasında negatif; serum tiroksin (T4) düzeyi ile ise pozitif korelasyon vardı (r:0.59)(p<0.001). Vücut kitle indeksi (VKI) SDS değeri bütün gruplarda yüksek idi. Son muayenede Grup 1 VKİ SDS değeri (- 0.4 + 0.6), Grup 3'e göre (1.1 ± 0.6) daha düşük idi. Puberte kızlarda normal yaşta başladı (n:30) (10.9 + 1.4 yıl) ancak hızlı seyretti. Sonuç olarak KPH'li hastalar, erken ve uygun tedavi ile yeterli boya ulaşabilmektedir. Serum T4, TSH düzeyleri ve kemik yaşı tayini hipotiroidinin izlem kriterleri içinde önemlidir.
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  • 1-2
26-30
  • Turkish

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