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KARACİĞER SİROZUNDA ORTALAMA ERİTROSİT HACMİNİN DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Evaluation ofthe mean corpuscular volume (mcv) in liver cirrhosis. Introduction and aim: In chronic liver diseases some changes in hematologic parameters are observed. The aim of this study is to investigate the relationship between MCV and aetiology as well as the severity of liver cirrhosis. Our patients (n:358) were divided into three groups; cirrhosis due to alcohol (group I), alcohol associated with any other aetiologic factors (group II) and any aetiologic factor other than alcohol (group III). MCV values in each group were determined and compared. We also inves-tigated the relationship betvveen MCV values and the Child-Pugh's stage. MCV values were found to be significantly higher in Child B than Child A and Child C than Child B (Child A-B p<0.001, Child B-C p<0<001, Child A-C p<0.0001). MCV values and Child-Pugh scores were found to have positive correlation and increased each other (r=0.3 p<0.01). Macrocytosis is frequently encountered also in liver cirrhosis due to causes other than alcohol. MCV values increase parellel to hepatic dysfunction.
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Abstract (Original Language): 
Kronik karaciğer hastalıklarında hematolojik parametrelerde değişiklikler sık görülmektedir. Bu çalışmanın amacı, karaciğer sirozunun etiyolojisi ve karaciğer fonksiyon bozukluğunun derecesi ile ortalama eritrosit hacmi (MCV) arasındaki ilişkileri araştırmaktır. Karaciğer sirozu tanısı konmuş 358 vaka, alkole bağlı, alkol ve bir başka etiyolojiye bağlı ve alkol dışı etiyolojiye bağlı olan karaciğer sirozu olmak üzere üç grupda incelenmiştir. Ortalama eritrosit hacmi ile Child-Pugh evrelemesi arasındaki ilişkiler araştırılmıştır. MCV, Child C olan vakalarda, Child A ve B'ye göre, Child B olan vakalarda ise Child A'ya göre anlamlı derecede yüksek bulunmuştur (Child A-B p<0.001, Child B-C p<0<001, Child A-C p<0.0001). Child-Pugh skoru ile ortalama eritrosit hacmi arasında pozitif korelasyon saptanmıştır (r=0.3, p<0.001). Makrositoz, alkol dışı etiyolojiye bağlı karaciğer sirozu vakalarında da sık görülmektedir. Ortalama eritrosit hacmi, karaciğer fonksiyon bozukluğuna paralel olarak artmaktadır
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PDF icon arastirmax-karaciger-sirozunda-ortalama-eritrosit-hacminin-degerlendirilmesi.pdf
  • 4
296-300
  • Turkish

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