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YENİ TEŞHİS EDİLMİŞ VE TEDAVİ GÖRMEMİŞ 23 KRONİK LENFOSİTIK LÖSEMİ VAKASININ KLİNİK, LABORATUVAR VE KEMİK İLİĞİ HİSTOPATOLOJİSİ SONUÇLARININ DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The evaluation of clinical, laboratory and histopathological results of 23 newly diagnosed and untreated CLL cases. We compared bone marrow biopsies according to age, number of lymphoid tissues involved, peripheric blood lymphocyte count, anemia, thrombocytopenia, percentage of lymphocytes in bone marrow aspirate, beta2-microglobulin level as well as similarities between clinical staging systems in chronic lymphocytic leukemia patients. 23 newly diagnosed CLL cases (mean age:61±ll years, 17 male, 6 female) were divided into three groups according to bone marrovv biopsy findings. We detected diffuse infiltration in 8, mixed infiltration in 10 and interstitial infiltration in 5 cases. In ali patients with thrombocytopenia we observed diffuse infiltration. Although it was not statistically significant, an increase in peripheric blood lymphocyte count was evident (p=0.065). Cervical lymphadenopathy was more common in the same group of patients (p=0.023). According to Rai and IWCLL staging systems, diffuse bone marrovv infiltration was more common in advanced whereas interstitial infilatration more evident in early stages of disease. No correlation was found between Binet staging system and bone marrovv biopsy findings. Three of 5 patients with interstitial infiltration presented vvifhout any symptom or sign of CLL.
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Abstract (Original Language): 
Kronik lenfositer lösemili hastalarda kemik iliği biyopsi bulguları ile yaş, tutulan lenfoid bölge sayısı, periferik kan lenfosit sayısı, anemi, trombositopeni, kemik iliği aspirasyonundaki lenfosit yüzdesi, P2-mikroglobulin düzeyleri ve klinik evreleme sistemleri arasındaki bağlantılar karşılaştırılmıştır. Yeni teşhis edilmiş, yaş ortalamaları 61 + 11 yıl olan, 17 erkek, 6 kadın toplam 23 vaka kemik iliği bulgularına göre üç guruba ayrıldı. Diffüz infiltrasyon 8, mikst infiltrasyon 10, intertisyel infiltrasyon 5 vakada saptandı. Trombositopeni saptanan vakaların hepsinin kemik iliği biyopsisinde diffüz infiltrasyon görüldü. Diffüz infiltrasyon görülen vakalarda istatistiksel anlamlılık olmamakla beraber belirgin olarak periferik kan lenfosit sayısında artış tespit edildi (p:0.065). Bu gurup vakalarda servikal lenfadenomegalinin daha sık olduğu bulundu (p:0.023). Rai ve IWCLL evrelemelerine göre ileri evrelerde diffüz, erken evrelerde interstisyel tip kemik iliği infiltrasyonu daha sık olarak görüldü. Binet evrelemesi ile biyopsi bulguları arasında korelasyon bulunamadı. İnterstisyel infiltrasyon saptanan 5 vakanın 3'ü semptomsuz olarak kliniğimize başvurmuş olup, interstisyel infiltrasyon saptanan vakaların hiç birinde herhangi bir organomegaliye rastlanmadı.
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PDF icon arastirmax-yeni-teshis-edilmis-tedavi-gormemis-23-kronik-lenfositik-losemi-vakasinin-klinik-laboratuvar-kemik-iligi-histopatolojisi-sonuclarinin-degerlendirilmesi.pdf
  • 4
150-155
  • Turkish

REFERENCES

References: 

1. Baccarani M, Cavo M, Gobbi M: Staging of chronic lymphocytic leukemia. Blood 59:1191 (1982).
2. Bartl R, Frisch B, Burkhardt R, Hoffmann-Fezer G, Demmler K, Sund M: Assessment of bone marrow trep-hine in relation to staging in chronic lymphocytic leukemia. Br J Haematol 51:1(1982).
3. Binet JL, Auquiner A, Dighiero G, Chastang C, Piguet H, Goasguen J, Vaugier G, Potron G, Colona P, Oberling F, Thomas M, Tchernia G, Jacquillat C, Boivin P, Lesty C, Duault T, Monconduit M, Belabbes S, Gremy F: A new prognostic classification of chronic lymphocytic leukemia derivaled from a multivariate survival analysis. Cancer48: 198 (1981).
4. Binet JL, LePorier M, Dighiero G: Clinical staging for chronic lymphocytic leukemia, prognostic significance. Cancer40: 855 (1977).
5. Boggs DR, Sofferman SA, Wintrobe MM: Factors inflıı-encing the duration of survival of patients with chronic lymphocytic leukemia. Anı J Med 40:243 (1996).
6. Constantinides P, Pathouli C, Kaı vountzis G, Papadopo-ulos P, Vartoutsi-Constattinides M, Eliakis P, Hadziyan-nis S, Komninos Z: Serum p2-microglobulin in malignant lymphoproliferative disorder. Cancer 55: 2384 (1985).
7. Flora SD, Forci F: Bone marrow patterns and clinical staging in chronic lymphocytic leukemia. Lancet 2:1269 (1977).
8. Foerster J. Edit by. Bithell TC, Lee GR, Foerster J, Wat-hens J, Lukens JN: Chronic lymphocytic leukemia. In
Sürücü H., Dinçol G., Doğan Ö., Nalçacı M., Keskin H.
Wintrobe Heamatol.ogy London, Philadelphia (1993) sayfa:2034
9. Freadman AS, Body A W, Bieber FR, Daley J, Rosen K, Horovvitz JC, Levy DN, Nadler LM: Normal cellular co-unterparts of B celi chronic lymphocytic leukemia. Blood 70:418 (1987), .,
10. Frish B, Bartl R: Histologic classification and staging of chronic lymphocyttcleukemia: A retrospective and pros-pective study of 503 cases. Açta Haematol 79:140 (1988).
11. Gale RP, Foon AK: Biology of chronic lymphocytic leukemia. Semin Haematol 24:209 (1987).
12. Geisler C, Ralfkier E, Hansen M, Hou-jensen K, Larsen SO: The bone marrovv histological patterns has indepen-dent prognostic value in early stage chronic lymphocytic leukemia. Br J Haematol 62:47 (1986).
13. International vvorkshop on chronic lymhocytic leukemia. Proposal for a revised prognostic staging system. Br J Haematol 48:365 (1981).
14. Lee JS, Dixon DO, Kantarjian HM, Keating MJ, Talpaz M. Prognosis of chronic lymhocytic leukemia: A multi-variate regression analysis of 325 untreated patients. Blood 69:929 (1987).
15. Melio L, Musto P, Tomasi P: Serum |32-microglobulin in malignant lymphopıoliferating disease. Tumor 74:129 (1988).
16. Montserrat E, Gomis F, Vallespi T, Rios A, Romero A, Soler J, Alcala A, Orey M, Ferran C, Diaz-Mediavialli J, Flores A, Woessner S, Battle J, Gonzalez-Aza C, Rovira M, Reverter JC, Rozman C: Presenting future and prognostic of chronic lymphocytic leukemia in younger adults. Blood 78:1545 (1991).
17. Montserrat E, Rozman C: Subclasification chronic lymphocytic leukemia with prognostic and therapeutic implications. Lancet 2:854 (1979).
18. Pangalis AG, Roussou PA, Kitas C, Mitsoulis-Mentzi-koff C, Matsouka-Alexandidis M, Anagnostopoulos N, Rombos I, Fessas P: Patterns of bone marrovv involment
in chronic lymphocytic leukemia and small lymphocy-tic(well differantiated) non-Hodgin lymphoma, Cancer 54:702 (1984).
19. Pangalis GA, Roussou PA, Kittas C, Kokkinou S, Fessas PB: Chronic lymphocytic leukemia? prognostic implica-tion of bone marrovv histology in 120 patients experience from a single hematology unit. Cancer 59: 767 (1987).
20. Rai KR, Boggs DR Savvitsky A, Cronkite E P et al: Clinical stage of Chronic Lymphocytic Leukemia. Blood 46: 219 (1975).
21. Rai KR, Montserrat E: Prognostic factors in chronic lymphocytic leukemia.-Senun Haematol 24; 252 (1987).
22. Rai KR, Patel DV: Edit by Hoffman R, Benz EJ, Shattil JS, Furie B, Colsen JH, Silbernstein LE. Chronic lymphocytic leukemia. In Hoffman Hematology (1995) Sayfa: 1308. Nevv York, Edinburg, London, Madrid, Melbourne, Milan, Tokyo
23. Rozman C, Montserrat E, Feliu E, Marin P, Nomdedeu B, Vives-Corrons JL: Prognosis of chronic lymphocytic leukemia:A multivariate survival analysis of 150 cases. Blood 59:1001(1982).
24. Rozman C, Montserrat E, Rodriquez-Fernandez JM, Ayats R, Vallespi T, Parody R, Rios A, Prados D, Moıey M, Gomis F, Alcala A, Gutierrez M, Maldonado J, Gon-zalez C, Giralt M, Hernandez-Nieto L, Cabrera A, Fer-nandez-Ranada JM: Bone marrovv histologic pattern the best single prognostic parameter in chronic lymphocytic leukemia: multivariate survival analysis of 329 cases. Blood 64: 642 (1984).
25. Rundles WR, Moore J: Chronic lymphocytic leukemia. Cancer 42:941 (1978).
26. Terri RT, Royston I, Lebien TW, Kay NE: Chronic lymphocytic leukemia progenitor cells carry the antigen T65.BA-1 and HLA-DR. Blodd 61:871 (1983).
27. Zengin N, Kars A, Sungur A, Zengin Nİ, Hayran M, Te-kuzman G, Kansu E, Ruacan Ş, Frat D: The signifance of bone marrovv biopsy pattern in chronic lymphocytic leukemia: A prognostic dilemma. Am J Haematol 62:208 (1999).

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