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ŞİŞMAN KADIN HASTALARDA PLAZMA LEPTİN DÜZEYLERİ; YAĞ MİKTARI, DAĞILIMI VE İNSÜLİN DÜZEYLERİ İLE İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Leptin concentrations in relation to overall adiposity, fat distribution and plasma insülin le-vels in obese women. The aim of this study is to examine the associations between leptin le-vels and BMI, fat distribution and serum insülin levels in obese women. 125 premenouposal obese women and 25 normal-vveight women participated in the study. Leptin levels in obese women were significantly higher than controls (26.4+16.8 vs 11.7+4.9 ng/mL, p<0.001). In obese women, leptin levels were significantly correlated with BMI (r: 0,3433), vvaist circumfe-rence (r: 0.3278), insülin (r: 0,2466) and HOMA (r: 0,2971). Our data suggested a significant relationship between leptin concentration and BMI (a surrogate for overall adiposity) and indi-cated that leptin levels might be a marker for the existence of insülin resistance.
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Abstract (Original Language): 
Diabetik olmayan menopoz öncesi şişman kadınlarda plazma leptin düzeyleri ile vücut yağ miktarı, yağ dağılımı ve insülin düzeyleri arasındaki ilişkiyi araştırmak amacıyla 125 preme-nopozal şişman kadın ve 25 normal ağırlıklı kadın çalışma kapsamına alındı. Şişman kadınlarda leptin düzeyi normal ağırlıklı kadınlardan anlamlı olarak yüksek bulundu (26.4+16.8 ve 11.7+4.9 ng/mL, p<0.001), ayrıca leptin düzeyleri ile BMI (r: 0,3433), bel çevresi (r: 0.3278), insülin (r: 0,2466) ve HOMA (r: 0,2971) arasında anlamlı ilişkiler bulundu. Bulgular, şişman kadınlarda leptin düzeyleri ve BMI ile temsil edilen total vücut yağlanması arasında anlamlı ilişkilerin bulunduğunu ve leptin düzeylerinin bir insülin direnci göstergesi olabileceğini yansıtmaktadır.
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  • 1
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  • Turkish

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