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ŞİŞMAN KADIN HASTALARDA PLAZMA LEPTİN DÜZEYLERİ; YAĞ MİKTARI, DAĞILIMI VE İNSÜLİN DÜZEYLERİ İLE İLİŞKİSİ

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Abstract (2. Language): 
Leptin concentrations in relation to overall adiposity, fat distribution and plasma insülin le-vels in obese women. The aim of this study is to examine the associations between leptin le-vels and BMI, fat distribution and serum insülin levels in obese women. 125 premenouposal obese women and 25 normal-vveight women participated in the study. Leptin levels in obese women were significantly higher than controls (26.4+16.8 vs 11.7+4.9 ng/mL, p<0.001). In obese women, leptin levels were significantly correlated with BMI (r: 0,3433), vvaist circumfe-rence (r: 0.3278), insülin (r: 0,2466) and HOMA (r: 0,2971). Our data suggested a significant relationship between leptin concentration and BMI (a surrogate for overall adiposity) and indi-cated that leptin levels might be a marker for the existence of insülin resistance.
Abstract (Original Language): 
Diabetik olmayan menopoz öncesi şişman kadınlarda plazma leptin düzeyleri ile vücut yağ miktarı, yağ dağılımı ve insülin düzeyleri arasındaki ilişkiyi araştırmak amacıyla 125 preme-nopozal şişman kadın ve 25 normal ağırlıklı kadın çalışma kapsamına alındı. Şişman kadınlarda leptin düzeyi normal ağırlıklı kadınlardan anlamlı olarak yüksek bulundu (26.4+16.8 ve 11.7+4.9 ng/mL, p<0.001), ayrıca leptin düzeyleri ile BMI (r: 0,3433), bel çevresi (r: 0.3278), insülin (r: 0,2466) ve HOMA (r: 0,2971) arasında anlamlı ilişkiler bulundu. Bulgular, şişman kadınlarda leptin düzeyleri ve BMI ile temsil edilen total vücut yağlanması arasında anlamlı ilişkilerin bulunduğunu ve leptin düzeylerinin bir insülin direnci göstergesi olabileceğini yansıtmaktadır.

REFERENCES

References: 

1. Arch JRS, Stock MJ, Trayhurn P: Leptin resistance in obese humans. Does it exist and what does it mean. Int J Obes 22: 1159 (1998).
2. Armitage P, Berry G: Statistical Methods in Medical Research, Blackwell, Oxfoıd, 2.Baskı, (1987).
3. Collins S, Sunvit RS: Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271: 9437 (1996).
4. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292 (1996).
5. Cusin I, Sainsbury A, Böyle P, Rohner-Jeanrenaud F, Je-anrenaud B: The ob gene and insülin. A relationship lea-ding to clues to the understanding of obesity. Diabetes 44: 1467(1995).
6. Dawson-Saunders B, Trapp RG: Basic and Clinical Bios-tatistics. Appleton & Lange, Connecticut, (1994).
7. Despres JP: Dyslipidemia and obesity. Bailliere's Clin Endocrinol Metab 8: 629 (1994).
8. Despres JP, Prud'lıomme D, Pouliot MC, Tremblay A, Bouchard C: Estimation of deep abdominal adipose tis-sue accumulation from simple anthropometric measure-ments in men. Am J Clin Nutr 54: 471 (1991).
9. Haffner SM, Gingeıich RL, Miettinen H, Stern MP: Leptin concentrations in relation to overall adiposity and re-gional body fat distribution in Mexican Americans. Int J Obesity 20: 904(1996).
10. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increa-sed obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1: 953 (1995)
11. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS: Relationship of plasma leptin to plasma insülin and adiposity in normal \veight and over-weight women. Effects of dietary fat content and sustai-ned vveight loss. J Clin Endocrinol Metab 81: 4406 (1996).
12. Houmard JA, Wheeler WS, McCammon MR, Well JM, Truitt N, Hamad SF, Holbert D, Israel RG, Barakat HA: An evaluation of waist to hip ratio measurement methods in relation to lipid and carbohydrate metabolism in men. Int J Obes 15: 181(1991).
13. Hu FB, Chen C, Wang B, Stampfer MJ, Xu X: Leptin concentrations in relation to overall adiposity, fat distribution and blood pressure in a rural Clıinese population. Int J Obes 25: 121 (2001).
14. Keesey RE, Hirnoven MD: Body weight set-point. De-termination and adjusment. J Nutr 127: 1875 (1997).
Bostancı B., Ozbey N., Kazancıoğlu R., Orhan Y.
15. Lonnqvist F, Arner P, Nordfors L, Schalling M: Ove-rexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Met 1: 950 (1995).
16. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M: Radioimmunoassay of leptin in human plasma. Clin Chem42: 942(1996).
17. MacDougald OA, Hwang CS, Fan H, Lane MD: Regula-ted expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci 92: 9034 (1995).
18. Matthevvs DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assess-ment: Insulin resistance and beta-cell function from fas-ting plasma glucose and insülin concentrations in man. Diabetologia 28: 412 (1985).
19. Misra A, Garg A: Leptin. Its receptor and obesity. J In-vest Med 44: 540(1996).
20. Pratley RE, Nicolson M, Bogardus C, Ravussin E: Effect of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insülin resistant Pima Indi-ans. J Clin Endocrinol Metab 81: 4418 (1996).
21. Ryan AS, Elahi D: The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels. Its relati-onships with body fat, visceral adiposity and age in wo-men. J Clin Endocrinol Metab 81: 4433 (1996).
22. Schwartz MW, Seeley RJ: Neuroendocrine responses to starvation and weight loss. New Engl J Med 336: 1802 (1997).
23. Seidell JC, Björntorp P, Sjöstöm L, Sannerstedt R, Krot-kiewski M, Kvist H: Regional distribution of muscle and fat mass in men. New insight into the risk of abdominal obesity using computed tomography. Int J Obes 13: 289 (1989).
24. Trayhurn P, Thomas MEA, Duncan JS, Rayner DV: Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese mice. FEBS Let-ters 368: 488 (1995).
25. Zimmet PZ, Collins V, deCourten M, Hodge AM, Colli-er GR, Dowse GK, Alberti KG, Tuomilehto J, Hemraj F, Gareeboo H, Chitsou P, Farred D: Is there a relationship betvveen leptin and insülin sensitivity independent of obesity. A population-based study in the Indian Ocean nationof Mauritus. IntJObes21: 171 (1998).

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