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DEMİR EKSİKLİĞİ ANEMİSİ VE DEMİR TEDAVİSİNİN PLAZMA TİROİD HORMON DÜZEYLERİNE ETKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The effect of iron-deficiency anemia and iron treatment on plasma thyroid hormone levels. To determine of possible alterations in plasma triiodothyroinine (T3) and thyroxine (T4) levels in patients with iron deficiency anemia (IDA) Subjects and Method: Thirty women (mean age 37,9+1,9 yr) with IDA and euthyroid clinic and 26 controls (mean age 34,7±1,4 yr) were enrolled in this study. Hemoglobin, hematocrite, serum iron, serum iron binding capacity, ferritin, T3, T4, and thyrotropin (TSH) measurements were performed in both gıoups at basal state and repeated after oral iron supplementation of three months in IDA group. At basal state T3 and T4 levels of IDA group were significantly lower than controls (4,7+0,2 vs. 5,3+0,1 pmol/1 and 14,3+0,5 vs. 16,5+0,2 pmol/1; p=0,009 and p<0,001, respectively). The mean TSH levels of IDA group was not different from controls (p>0,05). After iron supplementation there were significant increase in T3 (5,4(0,3 pmol/1; p=0,022) and T4 (16,1+0,8 pmol/1; p=0,037) and decrease in TSH (2,5+0,4 vs. 1,7+0,3 ulU/ml; p=0,009) when compaıed with basal levels. The differences between IDA group and controls with respect to thyroid hormone levels were disappeared after iron supplementation. We propose that IDA and iron supplementation have a significant role on thyroid hormon levels.
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Abstract (Original Language): 
Demir eksikliği anemisi (DEA) olan hastalarda plazma triiodotironin (T3) ve tiroksin (T4) düzeylerinde bir değişikliğin olup olmadığını saptamaktır. Hastalar ve Yöntem: Bu çalışmaya DEA ve ötiroid kliniği olan 30 kadın (ortalama yaş 37,9+1,9 yıl) ve 26 kontrol (ortalama yaş 34,7+1,4 yıl) alındı. Hemoglobin, hematokrit, serum demir, serum demir bağlama kapasitesi, ferritin, T3, T4 ve tirotropin (TSH) ölçümleri bazal durumda her iki grupta ve üç aylık demir tedavisinden sonra da DEA olan grupta tekrarlandı. Bazal durumda, DEA olan grupta T3 ve T4 düzeyleri kontrollerden anlamlı olarak daha düşük saptandı (sırasıyla 4,7+0,2'ye karşılık 5,3+0,1 pmol/1 ve 14,3±0,5'e karşılık 16,5+0,2 pmol/1; p=0,009 ve p<0,001). TSH açısından anlamlı bir fark yoktu (p>0,05). Demir tedavisinden sonra bazal değerlere göre T3 (5,4+0,3 pmol/1; p=0,022) ve T4 (16,1+0,8 pmol/1; p=0,037) düzeylerinde anlamlı bir yükselme olurken TSH düzeylerinde anlamlı bir düşme oldu (2,5+0,4'ten 1,7±0,3 ulU/ml'ye; p=0,009). Tiroid hormonları açısından DEA grubu ile kontroller arasındaki farklar üç aylık demir tedavisinden sonra kayboldular. DEA'nin ve demir tedavisinin tiroid hormon düzeyleri üzerinde önemli bir rolünün olduğu görüşündeyiz.
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  • 2
125-128
  • Turkish

REFERENCES

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