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HİPERLİPİDEMİLİ HASTALARDA SUBKLİNİK HİPOTİROİDİ SIKLIĞI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Prevalance of subclinical hypothyroidisın in patiems wİ(lı hyperİipidemia. Hypothyroidİstn İs a cause of secondary hyperİipidemia. The objeetives of this study were to document the prevalance of subclinical hypothyroidism in patients with hyperİipidemia. Study group is composcd of 747 hyperlipidemic patients admitted our outpatient lipid cünic (mcan age of the patients was 48.34 ± 11.28 years, 237 male, 510 vvomen), Criteria for diagnosis of hyperİipidemia we-re eholesterol and/or triglyceride levels greater than 200 mg/dL. Patients with conditions that may affect serum lipid profile or taking medications known to İnfluence plasma lipid concent-ration were excluded from the study. Subclinical hypothyroidism was defİned as a TSH level greater than 4.4 uU/mL in the presence of a normal free thyroxine level (11 to 25 pmol/L). Euthyroidism vvas defined as a normal TSH level (0.4 to 4.4 uU/mL) and a normal free tfıyro-xine level. Subclinical hypothyroidism was present in 3.6% of patients. Lipid profile, body mass index and arterial blood pressure levels were conıpared betv/een patient with subclinical hypothyroidism and patient with euthyroid patients. No signifıcant differences vvere found between the groups. These results suggest that ali patients referred for diagnosis of hyperİipidemia should be sereened for thyroid funetions.
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Abstract (Original Language): 
Hipotiroidi sckonder hiperiipidemi nedenlerinden birisidir. Bu çalışmanın amacı hiperiipidemi tanısı konulan hastalarda subklinik hipotiroidi sıklığını araştırmaktı. Çalışma kapsamına hiperlipidemi polikliniğine başvuran 747 hasta aimdı (237 erkek, 510 kadın, ortalama yaş 48.34 ± 11.28 yıl). Kolesterol ve trigliserid değerlerinden birisinin veya her ikisinin birlikte 200 mg/dL üzerinde bulunması hiperiipidemi olarak kabul edildi. Lipid profilini etkileyen herhangi bir hastalığı olan veya ilacı kullanan hastaiar değerlendirmeye alınmadı. Hastalar serbest T4 (sT4) ve TSH değerlerine göre ötiroid (sT4: 10 - 25 pmol/L, TSH: 0.4 - 4.4 uU/mL arası) ve subklinik hipotiroid (sT4: 10 - 25 pmol/L, TSH: 4.4 - 9.9 uU/mL arası) olmak üzere iki gruba ayrıldı. Bu düzeylere göre hastaların %3.6'sı subklinik hipotiroidi idi. Subklinik hipotiroidİk hastalarla ötiroid hastalar lipid profili, vücut kitle indeksi ve arter kan basıncı değerleri yönünden karşılaştırıldı. Gruplar arasında anlamlı farklılık bulunmadı. Çalışmanın sonuçları hiperiipidemi tanısı konulan hastaların tiroid fonksiyonlarının da değerlendirilmesi gerektiğini düşündürmektedir.
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  • 1
24-27
  • Turkish

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