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KRONİK HEMODİYALİZ HASTALARI İLE PERİTON DİYALİZİ HASTALARININ KLASİK KORONER RİSK FAKTÖRLERİ VE HOMOSİSTEİN DÜZEYLERİ AÇISINDAN KARŞILAŞTIRILMASI

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Abstract (2. Language): 
Comparison ofchronic hemodialysis patients and peritoneal dialysis patients İn terms oftra-ditional coronary risk factors and honıocysteine levels. Cardiovascular complications are majör factors affeeting the morbidity and mortaiity of dialysis patients. In the present study, the tradİtİonal cardiovascular risk factors and another important risk factor, homoeysteine levels, wcre invesligatcd in patients on hemodialysis (HD) therapy (n=30) and on continuous ambula-tory peritoneal dialysis (CAPD) therapy (n=3ü). The patients were searehed for family history for cardiovascular disease, smoking history, hypertension and hypervolemia, whüe serum levels of total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, homoeysteine and C-reactive protein (CRP) were measured. Serum total cholesterol, triglyceride and CRP levels were sigtıificantly elevated in CAPD patients compared to HD patients. Homoeysteine levels werc markedly inereased in both groups of patients. However, there was no difference in homoeysteine levels between the groups. In conelusion, hyperhomocysteinemia is an indepen-dent risk factor for cardiovacular disease in patients on dialysis and the modality of dialysis does not have a signİficant effect on serum homoeysteine levels.
Abstract (Original Language): 
Diyaliz hastalarında kardiyovasküler kompîikasy onlar mortalite ve morbiditcyi etkileyen en önemli faktörlerdendir. Çalışmamızda ünitemizde hemodiyaliz (HD) ve sürekli ayaktan periton diyalizi (SAPD) tedavisi gören hastaları klasik koroner risk faktörleri ve yine önemli bir risk faktörü olarak kabul edilen homosistein düzeyleri açısmdan karşılaştırdık. 30 HD ve 30 SAPD hastası aile öyküleri, sigara içimi, hipertansiyon, hİpervolemi varlığı konusunda sorgulanırken, total kolesterol, trigliserid, HDL-kolesterol, LDL-kolesterol, homosistein ve C-reak-tif protein (CRP) düzeyleri ölçüldü. Kolesterol, trigliserid vc CRP düzeyleri SAPD grubunda anlamlı olarak daha yüksek bulunurken, homosistein düzeyleri her iki grupta da kontrol grubuna göre anlamlı olarak yüksek bulunmakla birlikte, gruplar arasında anlamlı bir fark bulunamamıştır. Sonuç olarak, homosistein, diyaliz hastalarında bağımsız bir koroner risk faktörüdür ve diyaliz tedavi şekli bu riski değiştirmemektedir

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