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FAZLA KİLOLU VE ŞİŞMAN KADINLARDA HİPERTANSİYON SIKLIĞI ve METABOLİK SENDROM

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Hypertension and Body Fat Amount and Distribııtion in Obese Women. The aim of this study is to examine incidence of hypertension and its relationship with body fat amount and distribu-tion in obese women. Hypertension was defined as blood pressure > 140/90 mm Hg. Study group consisted of 646 overweight (body mass index, BMI >25 kg/m2) and 2539 obese (body mass index, BMI > 30 kg/m2) women. Hypertension was found in 1388 (%43.61) women. Age (43.04 + 12.44 vs 36.41 ± 11.28 years), weight (93.38 ± 18.11 vs 84.78 ve 14.36 kg), BMI (37.94 ± 7.15 vs 34.07 ± 6.94 kg/m2), waist circumference (103.20+ 13.38 vs 95.90 ± 11.80 cm), hip circumference (123.96 ± 13.78 vs 118.20 + 11.40 cm), waist-to-hip ratio (0.834 ± 0.077 vs 0.811 ± 0.066), glucose (106.22 ± 32.76 vs 96.14 ± 22.63 mg/dL), uric acid (4.77 ± 1.36 vs 4.24 ± 1.13 mg/dL), cholesterol (217.17 ± 45.89 vs 201.29 ± 43.63 mg/dL), triglyceri-de (178.64 ± 140.53 vs 145.00 ± 103.78 mg/dL), insülin (17.67 ± 16.40 vs 13.60 ± 11.51 uU/dL), HOMA (4.68 ± 4.83-vs 3.21 ± 3.22), gamma GT (23.55 ± 18.42 vs 20.68 ± 15.01 U/dL) and total risk score (1.89 ± 1.15 vs 1.34 ± 1.06) levels werc significantly higher in hypertensive groups tlıan those in normotensives (p < 0.001 for gamma GT and p < .0001 for others). These metabolic anomalies that constitute a cluster of phenomena are known as pluri-metabolic syndrome. The high levels of insülin and HOMA in hypertensive patients have sug-gcsted that insülin resistance could play a role in the pathogenesis of this syndrome.
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Abstract (Original Language): 
Bu çalışma şişman kadınlarda hipertansiyon sıklığını ve damar basıncı ile çeşitli risk göstergeleri arasındaki ilişkiyi incelemek amacıyla yapıldı. Damar basıncının 140/90 mm Hg in üzerinde olması hipertansiyon kriteri olarak kabul edildi. 646 fazla kilolu (beden kitle indeksi, body mass index, BMI > 25 kg/m2) ve 2537 şişman (BMI > 30 kg/m2) toplam 3183 kadından 1388 inde (%43.66) hipertansiyon saptandı. Hipertansif kadınlarda damar basıncı normal olanlara göre yaş (43.04 ± 12.44 ve 36.41 ± 11.28 yıl), ağırlık (93.38 + 18.11 ve 84.78 ve 14.36 kg), BMI (37.94 ± 7.15 ve 34.07 ± 6.94 kg/m2), bel çevresi (103.20 + 13.38 ve 95.90 ±11.80 cm), kalça çevresi (123.96 ± 13.78 ve 118.20 ±11.40 cm), bel-kalça oranı (0.834 ± 0.077 ve 0.811 + 0.066), glukoz (106.22 ± 32.76 ve 96.14 ± 22.63 mg/dL), ürik asit (4.77 ± 1.36 ve 4.24 + 1.13 mg/dL), kolesterol (217.17 ± 45.89 ve 201.29 ± 43.63 mg/dL), trigliserit (178.64 ± 140.53 ve 145.00 ± 103.78 mg/dL), insülin (17.67 ± 16.40 ve 13.60 ± 11.51 uU/L), HOMA (4.68 ± 4.83 ve 3.21 ± 3.22), gama GT (23.55 ± 18.42 ve 20.68 ± 15.01 U/L) ve toplam risk değeri (1.89 ± 1.15 ve 1.34 + 1.06) anlamlı daha yüksekti (p değeri gama GT için 0.001, diğerleri için 0.0001). HDL değerleri bakımından anlamlı bir farklılık bulunmadı. Hipertansif hastalarda diğer risk faktörlerinin birlikte bulunması metabolik sendrom varlığım destekler bulgu olarak kabul edildi. İnsülin ve HOMA düzeylerinin yüksek bulunması metabolik sendrom pa-togenezinde insülin direncinin yer alabileceğini düşündürmektedir.
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  • 3
140-144
  • Turkish

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