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PREEKLAMPTIK HASTALARDA ANTIOKSIDAN AKTIVITE VE LİPİD PEROKSİDASYONU ARASINDAKİ DENGENİN İRDELENMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Evahıaüon of the imbalance between antioxidant activity and lipid peroxidation in preec-lamptic patienls. The objective of this study is to test the hypothesis that maternal plasma lipid peroxİdatİon products are increased and antioxidants are decteased in women with mild pre-eclampsia. Fasting venous plasma were collected from normal pregnant (n=16) and mild pre-eclamptic women (n-16). Plasma total antioxidant status and thiobarbituric acid reactive substances (TBARS) were measured by colorimetric assay. Plasma maternal concentratİons of total antioxidant status and thiobarbituric acid reactive substances (TBARS) were not signifi-cantly differcnt in pre-eclampsia as compared with normal pregnancy (p> 0.05). When the va-riables in the same groups were measured, we found a negative correlation between total anti-oxidant status and TBARS in the normal group (r= -0.60, p<0.05). In the mild precclamplic women wc could not find a correlation betwcen total antioxidant status and TBARS (r=0.05, p>0.05). The findİngs in this study show that there is an imbalance between antioxidant defen-ces and lipid peroxidation İn precclamptic patients.
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Abstract (Original Language): 
Bu çalışmanın amacı preeklamptİk gebelerde kan lipid peroksidasyon ürünlerinin artması ve antioksidan düzeylerinin azalması ile ilgili hipotezi araştırmaktır. Bu amaçla normal gebe (n=16) ve preeklamptİk gebelerden (n=16) açlık venöz kanı alındı. Plazma total antioksidan aktivite ve tiyobarbitürik asitle reaksiyona giren maddelerin (TBARS) düzeyleri kolorimetrik yöntemle ölçüldü. Çalışmanın bulgularına göre normal ve preeklamptİk hamilelerin plazma total antioksidan aktivite değerleri ve TBARS değerleri arasında istatistiksel olarak anlamlı bir fark bulunamadı. Ayrıca sağlıklı gebe kadınlardan oluşan grupta total antioksidan aktivite ve TBARS değerleri arasında negatif yönde, orta güçte bir korelasyon tespit edildi (r=-0.60, p<0.05). Buna karşılık, preeklampsİli gebe kadınlardan oluşan grupta herhangi bir bağıntı tespit edilemedi (r=0.05, p>0.05). Bu bulgular ışığında preeklamptİk hastalarda antioksidan savunma sistemleri ve lipid peroksidasyonu arasında bir dengesizlik olduğu ileri sürülebilir.
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  • 3
149-152
  • Turkish

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