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NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ

A RETROSPECTIVE STUDY ON 100 NASOPHARYNGEAL CARCINOMA PATIENTS

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2006

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Abstract (2. Language): 
Objective: The aim of this retrospective study was to analyse the survival and recurrens patterns of 100 non-metastatic nasopharyngeal carcinoma patients. Materials and methods: A retrospective study in 100 nasopharyngeal carcinoma patients treated between 1991 and 2003 was performed. 76 received cisplatin based neoadjuvant chemotherapy for two or four courses prior to definitive radiotherapy and 24 were treated by radical radiotherapy alone. The total dose delivered to nasopharynx, lymph nodes and servical region (if affected) was 66-70 Gy, 50 Gy and 15-20 Gy respectively. Results: Twenty patients had stage II, 47 had stage III and 33 had stage IV disease (according to AJCC 1997 staging system). All patients were diagnosed as nasopharyngeal squamous cell carcinoma (18 WHO I-II and 82 WHO III). Minimum follow-up period was two years. Overall response after induction chemotherapy was 75% (with 13.2% complet response and 61.8% partial response). 13 patients had stable disease (17.1%), whereas 6 patients (7.9%) had progressive disease. Failure rate after radiotherapy was 53%. Locoregional recurrence was 56.6%, locoregional recurrence and distant failure was 28.3% and isolated distant failure was 15.1%. The five years overall survival was 57.1% for radiotherapy alone and 57.7% for the chemoradiotherapy. Conclusion: Induction chemotherapy neither improved the teratment outcome nor altered the failure patterns in patients with nasopharyngeal carcinoma.
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Abstract (Original Language): 
Amaç: Bu retrospektiv çal›flman›n amac›, nonmetastatik nazofarengeal karsinomlu 100 hastan›n survi ve rekürrens paternini analiz etmekti. Gereç ve yöntem : 1991-2003 y›llar› aras›nda tedavi edilen 100 nazofarengeal karsinomlu hasta retrospektif olarak incelendi. 24’ü yaln›z radyoterapi ile tedavi edilirken, 76’s›na kombine model tedavi (cisplatin bazl› 2-4 kür neoadjuvant kemoterapi ve radyoterapi) uygulanm›flt›. Nazofarengeal bölgeye 66-70 Gy, lenf nodlar›na 50 Gy, servikal hastal›k mevcut ise tutulan alana 15-20 Gy boost dozu verilmiflti. Bulgular: AJCC 1997 evreleme sistemine göre, hastalar›n 20’si evre II, 47’si evre III, 33’ü evre IV’tü. Tüm hastalar skuamoz hücreli nazofarengial karsinom tan›s› alm›flt› (18 WHO I-II, 82 WHO III). Minimum takip süresi 2 y›ld›. ‹ndüksiyon kemoterapisine yan›t oran› %75 (%13,2 tam ve %61,8 k›smi), yan›ts›z olanlar›n oran› (progresif hastal›k) %7,9 ve stabil hastal›k oran› %17,1’di. Radyoterapi sonras› baflar›s›zl›k oran› %53’tü. Bunlar›n %56,6’s› lokoregional nüks, %28,3’ü lokoregional nüks ve uzak metastaz ve %15,1’i izole metastazd›. 5 y›ll›k genel sa¤ kal› m yaln›z radyoterapi verilenlerde %57,1, kombine tedavi verilenlerde %57,7 idi. Sonuç: ‹ndüksiyon kemoterapisi nazofarengeal karsinomlu hastalarda tedavi sonuçlar›n› ve baflar›s›zl›k paternini de¤ifltirmemifltir.
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