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ANTİ-HCV POZİTİF HEMODİYALİZ HASTALARINDA ERİTROSİT VE SERUM FERRİTİN DÜZEYLERİ İLE KARACİĞER ENZİM DÜZEYLERİ ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ

THE EVALUATION OF RELATIONSHIP BETWEEN ERYTHROCYTE AND SERUM FERRITIN LEVELS WITH AMINOTRANSFERASE ENZYME LEVELS IN ANTI-HCV POSITIVE HEMODIALYSIS PATIENTS

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Serum ferritine level which is released from hepatocellular stores due to chronic inflammation of HCV infection, is accepted as an independent indicator of hepatocellular damage. It is not known whether intra-erythrocyte ferritin could be used as an indicator of hepatocellular damage as with serum ferritin, AST and ALT. In our study, we evaluated the relationship between aminotransferase level with eriythrocyte ferritin level and serum ferritin level in anti-HCV positive hemodialysis patients. Materials and methods: 40 HCV patients, taking hemodalysis therapy at five different hemodialysis center, were included in the study. They had no active inflamation, malignity and policytemia and had not been given blood transfusion. Erythrocyte and serum ferritin, ALT, AST, CRP, HBs-Ag, anti-HCV, anti-HIV levels were detected. The results were evaluated by using SPSS (ver.12) statistics program. Results : 17 male and 23 female patients were taken to study and their average age was 54 ± 16 year. Their alanineaminotransferase values were 25 ± 29 IU/L, their aspartat aminotransferase values 20 ± 12 IU/L, erythrocyte ferritin values 1.8 ± 1.72 ng/gHb and their serum ferritin values were 992 ± 424ng/ml. When the data evaluated, it was found that, there is a statistically significant positive correlation between the serum aminotransferase levels and the serum ferritin levels (p< 0.05), whereas there was no statistically significant pozitif correlation between aminotransferase levels and erythrocyte ferritin levels (p> 0.05). Conclusion: In HCV positive patients, AST, ALT and serum ferritin released from hepatoselluler stores shows liver damage. We found a significant positive correlation between aminotransferase levels and serum ferritin levels, but not with erythrocyte ferritin levels. This finding lead us to a conclusion that, erythrocyte ferritin levels are not a good marker for showing hepatocellular damage as like serum ferritin levels in HCV positive hemodialysis patients.
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Abstract (Original Language): 
ÖZET Amaç: Hepatit C enfeksiyonu olan hastalarda, kronik enflamasyona ba¤l› olarak hepatosellüler depolardan ferritin sal›nmakta ve bu hepatosellüler hasar›n ba¤›ms›z bir göstergesi olarak kabul edilmektedir. Serum eritrosit ferritin seviyelerinin, serum ferritin düzeyleri gibi, karaci¤er hasar›n› göstermede aminotransferazlar ile birlikte kullan›l›p kullan›lamayaca¤› bilinmemektedir. Çal›flmam›zda amac›m›z, anti-HCV pozitif hemodiyaliz hastalar›nda, karaci- ¤er hasar›n›n göstergesi olan aminotransferaz enzim düzeyleri ile eritrosit ve serum ferritin düzeyleri aras›ndaki iliflkiyi ortaya koymakt›r. Gereç ve yöntem: Befl farkl› diyaliz merkezinde diyalize giren, aktif enfeksiyonu, malignitesi ve polisitemisi bulunmayan, kan transfüzyonu yap›lmam›fl, anti- HCV’ si pozitif 40 hastada eritrosit ferritin, serum ferritin, CRP, HBsAg, anti-H‹V, anti-HCV, ALT (alaninaminotransferaz ) ve AST (aspartat aminotransferaz) düzeylerine bak›ld›. SPSS (ver. 12) istatistik program› kullan›larak sonuçlar de¤erlendirildi. Bulgular: Hastalar›n 17’ si erkek 23’ü kad›n olup yafl ortalamalar› 54±16 y›l, ALT 25 ±19 IU/L, 20±12 IU/L, eritrosit ferritin de¤erleri 1,8 ± 1,72 ng/gHb, serum ferritin de¤erleri 992±424 ng/ml olarak bulundu. Yap›lan de¤erlendirmede, serum aminotransferaz de¤erleri ile serum ferritin de¤erleri aras›nda istatistiksel olarak anlaml› pozitif korelasyon saptand› (p< 0,05), ancak eritrosit ferritin ile aminotransferazlar düzeyleri aras›nda istatistiksel olarak anlaml› pozitif korelasyon saptanmad› (p> 0,05). Sonuç: Anti-HCV pozitif hastalarda hepatosellüler depolardan sal›nan serum ferritin seviyeleri aminotransferaz enzimleri ile birlikte karaci¤er hasar›n›n göstergelerinden biridir. Yapt›¤›m›z çal›flmada, aminotransferaz seviyeleri ile serum ferritin düzeyleri aras›nda anlaml› korelasyon saptand›, ancak eritrosit ferritin düzeyleri ile aminotransferaz seviyeleri aras›nda anlaml› bir korelasyon saptanamam›flt›r. Bulgular HCV pozitif hemodiyaliz hastalar›nda, eritrosit ferritin seviyelerinin karaci¤er hasar›n› göstermede serum ferritin gibi iyi bir belirteç olarak kullan›lamayaca¤›- n› düflündürmektedir.
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