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AİLESEL AKDENİZ ATEŞİ’NDE BÖBREK TUTULUMU

RENAL INVOLVEMENT IN FAMILIAL MEDITERRANEAN FEVER

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Abstract (2. Language): 
Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disease characterized by recurrent attacks of fever, peritonitis, pleuritis and synovitis. The most serious manifestation of FMF is the development of systemic amyloidosis and non-amyloid renal pathologies. It begins insidiously causing proteinuria, then progresses to nephrotic syndrome, and eventually ends in renal failure. The overall incidence of amyloidosis in FMF has diminished markedly in the last 30 years, due to increased recognition and earlier diagnosis of this disease and the widespread use of colchicine.
Abstract (Original Language): 
Ailesel Akdeniz Atefli (AAA), otozomal resesif geçifl gösteren, tekrarlayan atefl, peritonit, plörit ve sinovit ataklar› ile karakterize kal›t›msal bir hastal›kt›r. AAA’nin en önemli özelli¤inden birisi sistemik amiloidoz ve amiloidoz d›fl› di- ¤er böbrek patolojilerine neden olmas›d›r. AAAile iliflkili amiloidoz, bafllang›çta proteinüri ile kendini gösterir, nefrotik sendrom ve böbrek yetmezli¤ine kadar ilerleyebilir. Son 30 y›lda hastal›¤a erken tan› koymak ve kolflisinle erken tedaviye bafllamakla, AAAile iliflkili amiloidoz insidans› giderek azalm›flt›r.
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