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OBEZ ÇOCUKLARDA PLAZMA GHRELİN, SERUM IGF-I VE IGFBP-3 DÜZEYLERİ

PLASMA GHRELIN, SERUM IGF-I AND IGFBP-3 LEVELS IN OBESE CHILDREN

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Obesity is defined as excessive fat accumulation in the body which, if not prevented, causes metabolic and hormonal disorders. Recognition of causes and pathophysiologic consequences of weight gain is imperative to develop both effective treatment and preventive measures. The purpose of this study was to determine levels of ghrelin, which is known as appetite hormone and stimulates the release of growth hormone (GH); and to investigate the association of ghrelin with growth factors IGF-I and IGFBP-3 in obese children as they have an already disturbed GH release. Materials and methods: Thirty-eight obese and 19 healthy children were included our study. Subjects who have included the study were measured fasting and postprandial ghrelin, IGF-I, IGFBP–3 and insulin levels. Results: Plasma ghrelin levels of obese children were found to be lower compared to normal children, whereas IGF-I and IGFBP-3 levels were higher. Negative correlations of ghrelin with BMI and IGF-1 levels were dedected in obese children. But a relation between ghrelin and IGFBP-3 levels was not found in this group. In the obese group, ghrelin levels of pubertal cases were lower compared to prepubertal cases, whereas this was higher for normal children. Metabolic changes driven by positive energy balance might suppress ghrelin levels in obese children. Negative correlation of ghrelin with IGF-1 levels was ascribed to hormonal changes caused by obesity. Conclusion: This study emphasizes that hormonal changes caused by obesity also include decreased levels of ghrelin.
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Abstract (Original Language): 
Amaç: Günümüzde obesite bir çok metabolik ve hormonal bozuklu¤a sebep olan bir hastal›k olarak kabul edilmektedir. Obez kiflilerde kilo al›m›n›n nedenlerinin ve patofizyolojik sonuçlar›n›n anlafl›lmas›, obesiteyi önleyici etkin tedavi ve korunma yöntemlerinin geliflmesine katk› sa¤layabilir. Bu çal›flmada, obez çocuklarda ghrelin düzeylerini ve büyüme faktörleri olan IGF-1 ve IGFBP-3 ile iliflkisini araflt›rd›k. Gereç ve yöntem: 38 obez ve 19 sa¤l›kl› çocuk çal›flmaya dahil edilmifltir. Çal›flmaya al›nan olgular›n açl›k ve tokluk ghrelin, IGF-I, IGFBP-3 düzeyleri ölçülmüfltür. Bulgular: Normal çocuklara k›yasla, obez olgular›n plazma ghrelin düzeyleri düflük, IGF-I ve IGFBP–3 düzeyleri ise yüksek bulundu (p<0,05). Obez olgularda, ghrelin düzeylerinin IGF-I ve vücut kitle indeksi ile negatif korelasyon gösterdi¤i belirlendi (p<0,05). Ancak bu grupta IGFBP-3 ve ghrelin düzeyleri aras›nda bir iliflki saptanmad›. Pubertal obezlerde ghrelin düzeyleri, prepubertal obezlere göre düflük bulunurken, normal çocuklarda pubertal ghrelin düzeyleri daha yüksekti. Obez olgularda pozitif enerji dengesi sonucu oluflan metabolik de¤iflikliklerin ghrelin düzeylerini bask›layabilece¤i düflünüldü. Ghrelin ile IGF-I düzeylerinin negatif iliflkisi, obezite sonucu oluflan hormonal de¤iflikliklere ba¤land›. Sonuç: Bu çal›flman›n sonucunda, ghrelin düzeylerindeki azalman›n, obeziteye ba¤l› geliflen hormonal de¤ifliklerden biri olabilece¤i düflünüldü.
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  • 2
47-51
  • Turkish

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