PLASMA GHRELIN, SERUM IGF-I AND IGFBP-3 LEVELS IN OBESE CHILDREN
Journal Name:
- İstanbul Tıp Fakültesi Dergisi
Keywords (Original Language):
| Author Name | University of Author | Faculty of Author |
|---|---|---|
Abstract (2. Language):
Objective: Obesity is defined as excessive fat accumulation in the body which, if not prevented, causes metabolic
and hormonal disorders. Recognition of causes and pathophysiologic consequences of weight gain is imperative to
develop both effective treatment and preventive measures. The purpose of this study was to determine levels of
ghrelin, which is known as appetite hormone and stimulates the release of growth hormone (GH); and to investigate
the association of ghrelin with growth factors IGF-I and IGFBP-3 in obese children as they have an already disturbed
GH release.
Materials and methods: Thirty-eight obese and 19 healthy children were included our study. Subjects who have
included the study were measured fasting and postprandial ghrelin, IGF-I, IGFBP–3 and insulin levels.
Results: Plasma ghrelin levels of obese children were found to be lower compared to normal children, whereas
IGF-I and IGFBP-3 levels were higher. Negative correlations of ghrelin with BMI and IGF-1 levels were
dedected in obese children. But a relation between ghrelin and IGFBP-3 levels was not found in this group.
In the obese group, ghrelin levels of pubertal cases were lower compared to prepubertal cases, whereas
this was higher for normal children. Metabolic changes driven by positive energy balance might suppress
ghrelin levels in obese children. Negative correlation of ghrelin with IGF-1 levels was ascribed to hormonal
changes caused by obesity.
Conclusion: This study emphasizes that hormonal changes caused by obesity also include decreased levels
of ghrelin.
Bookmark/Search this post with
Abstract (Original Language):
Amaç: Günümüzde obesite bir çok metabolik ve hormonal bozuklu¤a sebep olan bir hastal›k olarak kabul edilmektedir.
Obez kiflilerde kilo al›m›n›n nedenlerinin ve patofizyolojik sonuçlar›n›n anlafl›lmas›, obesiteyi önleyici etkin
tedavi ve korunma yöntemlerinin geliflmesine katk› sa¤layabilir. Bu çal›flmada, obez çocuklarda ghrelin düzeylerini
ve büyüme faktörleri olan IGF-1 ve IGFBP-3 ile iliflkisini araflt›rd›k.
Gereç ve yöntem: 38 obez ve 19 sa¤l›kl› çocuk çal›flmaya dahil edilmifltir. Çal›flmaya al›nan olgular›n açl›k ve tokluk
ghrelin, IGF-I, IGFBP-3 düzeyleri ölçülmüfltür.
Bulgular: Normal çocuklara k›yasla, obez olgular›n plazma ghrelin düzeyleri düflük, IGF-I ve IGFBP–3 düzeyleri
ise yüksek bulundu (p<0,05). Obez olgularda, ghrelin düzeylerinin IGF-I ve vücut kitle indeksi ile negatif korelasyon
gösterdi¤i belirlendi (p<0,05). Ancak bu grupta IGFBP-3 ve ghrelin düzeyleri aras›nda bir iliflki saptanmad›.
Pubertal obezlerde ghrelin düzeyleri, prepubertal obezlere göre düflük bulunurken, normal çocuklarda pubertal
ghrelin düzeyleri daha yüksekti. Obez olgularda pozitif enerji dengesi sonucu oluflan metabolik de¤iflikliklerin ghrelin
düzeylerini bask›layabilece¤i düflünüldü. Ghrelin ile IGF-I düzeylerinin negatif iliflkisi, obezite sonucu oluflan
hormonal de¤iflikliklere ba¤land›.
Sonuç: Bu çal›flman›n sonucunda, ghrelin düzeylerindeki azalman›n, obeziteye ba¤l› geliflen hormonal de¤ifliklerden
biri olabilece¤i düflünüldü.
- 2
47-51