Buradasınız

PAPİLLİT İLE SEYREDEN NÖROBRUSELLOZ OLGUSU

A CASE OF NEUROBRUCELLOSIS PRESENTING WITH PAPILLITIS

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Neurologic complications of childhood brucellosis are rarely seen. It usually presents as acute infection of central nervous system. A9-year-old female patient presented to our clinic with fatigue, severe headache, visual loss especially at right eye. She had a history of cheese ingestion made from unpasteurized milk four months ago. There was bilateral papilledema and hemorrhagia at optic discs in fundoscopic examination. Standart Brucella tube agglutination (Wright test) was positive at 1/320 titer and Coombs test was strongly positive at 1/1280 titer. Brucella IgG was also positive (ELISA) in cerebrospinal fluid examination. She was treated with doxycylin, rifampicin and gentamicin. Her clinical findings improved after treatment. No relapse was seen in 10-month follow-up period.
Abstract (Original Language): 
Brusellozisin çocukluk ça¤›nda nörolojik komplikasyonlar› nadir görülür ve genellikle santral sinir sisteminin akut enfeksiyonu fleklinde seyreder. Dokuz yafl›nda k›z hasta, klini¤imize halsizlik, fliddetli bafl a¤r›s›, sa¤ gözde daha belirgin olmak üzere bilateral görmede azalma flikayeti ile baflvurdu. Dört ay önce pastörize edilmemifl sütten yap› lm›fl peynir yeme hikayesi bulunan hastada, optik diskin fundoskopik muayenesinde bilateral papilla ödemi ve hemoraji vard›. Serumda standart brusella tüp aglütinasyon testi (Wright testi) 1/320 titrede (+), Coombs ile 1/1280 titrede (+), beyin omurilik s›v›s›n›n EL‹SA ile incelenmesinde brusella IgG (+) olarak saptand›. Doksisiklin, rifampisin ve gentamisin ile tedavi edildi. Tedaviden dört hafta sonra papilla ödemi geriledi ve 8 hafta sonunda tamamen iyileflti. On ayl›k izlemde relaps gözlenmedi.
61-64

REFERENCES

References: 

1. Akdeniz H, Irmak H, Anlar Ö, Demiröz AP. Central Nervous
System Brucellosis: Presentation, Diagnosis and Treatment.
Journal of ‹nfection 1998; 36: 297-301.
2. Al Deeb MS, Yaqub BA, Sharif HS, Phadke GJ. Neurobrusellozis
clinical characteristics, diagnozis and outcome, Neurology
1989; 39: 498-501.
3. American Academy of Pediatrics; Red Book 2003; 222-224.
4. Behrman RE, Kl›egman RM, Jenson HB. Nelson Textbook
of Ped›atr›cs. 17th Edition, 2004; pp 2120-2121.
5. Cecil Textbook of Medic›ne 22nd Ed›t›on 2004; 1888-1889.
6. Habeeb YK, Najdi AK, Sadek SA, Al-Onaizi E. Paediatric
neurobrucellosis: Case report and literature review. Journal
of Infection 1998; 37: 59-62.
7. Levy J, Shneck M, Marcus M, Lifshitz T. Brucella menengitis
and papilledema in a child. European Journal of Ophthalmology
2005; 15: 818-820.
8. Lulu AR, Araj GF, Khateeb MI, Mustafa MY, Yusuf AR, Fenech
FF. Human Brucellosis in Kuwait, A prospective study
of 400 cases. Quart J Med 1988; 249:39-54.
9. McLean DR, Russell N, Yousuf KM. Neurobrucellosis: clinical
and therpeutic features.Clinic Infection Disease 1992;
15:582-590.
10. Mousa ARM, Koshy TS, Araj GF. Brucella meningitis:presentation,
diagnosis and treatment, Aprospective study of ten
cases.Quart J Med 1986; 60:873-885.
11. Öz›fl›k HI, Ersoy Y, Tevfik MR, K›zk›n S, Özcan C. ‹solated
intracranial hypertansion: a rare presentation of neurobucellosis.
Microbes and Infection 2004; 6: 861-863.
12. Pellicer T, Ariza J, Foz A. Specific antibodies detected during
relapse of human brucellosis. J. Infect. Dis. 1988; 157 :
918-924.
13. Shakir RA, Al Din ASN, Araj GF, Lulu AR, Mouse AR, Saadah
MA. Clinical categories of neurobrusellozis a report on
19 cases, Brain 1987; 110: 213-223.

Thank you for copying data from http://www.arastirmax.com