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GENİŞ OPTiK SİNİR BAŞI ÇUKURLUĞU VE NORMAL GÖRME ALANI OLAN OLGULARDA OPTİK SİNİR BAŞININ HEIDELBERG RETİNA TOMOGRAFİSİ İLE DEĞERLENDİRİLMESİ

EXAMINATION OF THE OPTIC NERVE HEAD WITH HEIDELBERG RETINA TOMOGRAPHY IN EYES WITH LARGE OPTIC NERVE HEAD CUP AND NORMAL VISUAL FIELD

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Abstract (2. Language): 
Objective: To evaluate optic nerve head (ONH) topographic measurements with Heidelberg Retina Tomography in eyes with large ONH cup and (C/D ratio> 0.4) normal standard visual field. Materials and methods: Sixty-four eyes of 32 patients with large, physiologic ONH cups and normal standard visual fields were included in the study. The white-on-white visual fields (program 30-2) were obtained with Humphrey perimeter (Model 750). Intraocular Pressure (IOP) and Central Corneal Thickness (CCT) were measured with Goldmann applanation tonometer and ultrasonic pachymeter respectively. HRT with the software version 1.01 was used to evaluate the ONH topographic measurements Results: The mean age of patients were 44.25±14.0 years. Mean CCT was found 558.33±33.27μm. Mean IOP of the patients was 16.15±2.42 mmHg. We evaluated 32 eyes as normal (group 1) and 32 eyes as glaucoma (group 2) according to ONH analysis with HRT. Strong correlation was found between C/D ratio and glaucoma group with Mann Whitney U statistical analysis. Conclusion: The C/D ratio was found significantly smaller in normal group than in glaucoma group ( p<0.05). HRT reported 50% of the eyes whose clinical findings were normal, as having glaucoma. HRT may be useful for detection of glaucomatous change in subjects with large ONH cups in the long term followup. However, HRT results alone may be misleading in the diagnosis of glaucoma.
Abstract (Original Language): 
Amaç: Standart görme alanı normal ve optik sinir baĢı (OSB) çukurluğu 0,4 ve üzerinde olan hastaların Heidelberg Retina Tomografisi ile değerlendirilmesi. Gereç ve yöntem: OSB çukurluğu fizyolojik görünümlü ve Humphrey perimetresinin (750 model) 30-2 eĢik testiyle yapılan standart görme alanları normal olan, 32 hastanın 64 gözü çalıĢmaya alındı. Bütün olguların santral kornea kalınlıkları (SKK) ve Goldmann Aplanasyon tonometresi ile göz içi basınçları (GĠB) ölçüldü. OSB analizinde, konfokal laser tarayıcı oftalmoskop (Heidelberg Retina Tomografisi, HRT, software version 1.01 ) kullanıldı. Bulgular: Hastaların yaĢ ortalamaları 44,25±14,0 yıldı. Ortalama SKK değeri 558,33±33,27 μm idi. Ortalama GĠB değeri 16,15±2,42 mmHg idi. HRT sonucuna göre gözler OSB glokom ve normal çıkanlar olmak üzere iki sınıfa ayrıldı. Mann Whitney U istatistik testi ile incelendiğinde, C/D oranı arttıkça HRT‟ nin olguları glokom olarak değerlendirme olasılığının arttığı görüldü. Sonuç: HRT ölçüm sonuçlarına göre, normal çıkan gruptaki gözlerin glokom çıkan gruptaki gözlere göre C/D oranları anlamlı olarak daha azdı. (p<0,05). Klinik olarak normal kabul ettiğimiz olguların, %50‟si HRT‟de glokom olarak değerlendirildi. HRT geniĢ OSB çukurluğu olan olguların uzun dönemde glokom geliĢip geliĢtirmeyeceğini ortaya çıkarmada faydalı olabilir. Ancak baĢlangıçta tek baĢına yeterli bir teknik değildir.
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REFERENCES

References: 

1. Airaksinen PJ, Drance SM, Douglas GR, Mawson DK, Nieminen H. Diffuse and localized nerve fiber loss in glaucoma. Am J Ophthalmol 1998;96:566-657.
2. Anctil JL, Anderson DR. Early foveal involvement and generalized depression of the visual field in glaucoma. Arch Ophthalmol 1984;102:363-370.
3. Arenas-Archila E, Caycedo-Yunis F, Rodriguez MR. Evaluation and definition of physiologic macro cups with confocal optic nerve analysis (HRT). Int Ophthalmol 2001;23:239.
4. Armaly MF. Opticup in normal and glaucomatous eyes. Invest Ophthalmol 1970;9:425-429.
5. Britton RJ, Drance SM, Schulzer MD, Douglas GR, Mawson DK. The area of the neuroretinal rim of the optic nerve in normal eyes. Am J Ophthalmol 1987;103:497-504.
6. Buhrmans R. Clinical Epidemiology of Glaucoma. In Allingham RR, Damji KF, Freedman S, Moroi S,
Optik sinir baĢının Heidelberg Retina Tomografisi ile değerlendirilmesi
13
Examination of optic nerve head with heidelberg retina tomography
İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 73• Sayı / Number: 1 • Yıl/Year: 2010
Shafranov G (eds): Shield‟s Textbook of Glaucoma. Lippincott Williams and Wilkins. Philadelphia, USA. 5th ed, 2005; pp: 170-191.
7. Caprioli J, Miller JM. Optic disc rim area is related to disc size in normal subjects. Arch Ophthalmol 1987;105:1683-1685.
8. Danesh-Meyer HV, Ku JY, Papchenko TL, Jayasundera T, Hsiang JC, Gamble GD. Regional Correlation of structure and function in glaucoma using the disk damage likelihood scale, Heidelberg Retina Tomograph and Visula Fields. Ophthalmology 2001;108:1621-627.
9. Doughty MJ, Zaman M. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol. 2000;44:367-408.
10. Eid TM, Spaeth GL, Katz LJ, Azuara-Blanco A, Agusburger J, Nicholl J. Quantative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field. J Glaucoma 1997;6:221-230.
11. Garway-Heath DF, Ruben ST, Viswanathan A, Hitchings RA. Vertical cup/disc ratio in relation to optic disc size: Its value in the assesment of the glaucoma suspect. Br J Ophthalmol 1998;82:1118-1124.
12. Hatch WV, Flanagan JG, Williams-Lyn DE, Buys YM, Farra T, Trope GE. Interobserver agreement of Heidelberg retina tomograph parameters. J Glaucoma 1999;8:232-237.
13. Jonas JB, Papasthathopoulos KI. Optic disc shape in glaucoma. Graefes Arch Clin Exp Ophthalmol 1996; 234:167-173.
14. Jonas JB, Gusek GC, Naumann GO. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci 1992; 32:474-475.
15. Jonas JB, Gusek G, Naumann GO. Makropaillen mit physiologischer Makroexkavation.Papillometrischer Charakteristika in 17 Augen. Klin Monatsbl Augenheilkd, 1987;191:452-457.
16. Jonas JB, Zach FM, Gusek GC, Naumann GO. Pseudoglaucomatous physiologic large cups. Am J Ophthalmology 1989;5 systems for three-dimensional analysis of the optic papilla. Ophthalmologe 1993;90:613-619.
27. Sampaolesi R, Sampaolesi JR. Large optic nerve heads: megalopapilla or megalodiscs. International Ophthalmology 2001;23:251-257.
28. Saruhan A, Orgül S, Koçak I, Prünte C, Flammer J. Descriptive information of topographic parameters computed at the optic nerve head with the Heidelberg retina tomograph. J Glaucoma 1998; 7:420-429.
29. Siam GA, Gheith ME, de Barros DS, Lin AP, Moster MR. Limitations of the Heidelberg Retina Tomograph. Ophthalmic Surgery Lasers and Imaging 2008;39:262-264.
30. Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, Witt KA. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991;109:77-83.
31. Strouthidis NG, Scott A, Peter NM, Garway Heath DF. Optic disc and visual field progression in ocular
hypertensive subjects: detection rates, specifity and agreement. Invest Ophthalmol Vis Sci 2006; 47:2904-2910.
32. Tamçelik, N, ÖzkırıĢ A, Ünal M, Üstündağ C, Ocakoğlu Ö, Devranoğlu K, Özkan ġ. Göz içi basıncı normal ve optik sinir baĢı çukurluğu geniĢ olan olgularda Heidelberg Retina Tomografisi Sonuçlarımız. T Oft Gaz 2000; 30:262-265.
33. Tsai CS, Zangwill L, Gonzales C, Irak I, Garden V, Hoffamnn R, Weinreb RN. Ethnic differences in optic head nerve tomography. J Glaucoma 1995;4: 248-257.
34. Tuulonen A, Lehtola J, Airaksinen PJ. Nerve fiber layer defects with normal visual fields. Ophthalmology 1993;100:587-598.
35. Zeyen TG, Caprioli J: Progression of disk and field damage in early galucoma. Arch Ophthalmol. 1993;111;62-65.

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