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GENİTAL BÖLGEDE SEFTRİAKSONA BAĞLI GELİŞEN TOKSİK EPİDERMAL NEKROLİZİS VAKASI

A CASE OF CEFTRIAXONE-INDUCED TOXIC EPIDERMAL NECROLYSIS IN GENITAL AREA

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
We present a 2-year-old Turkısh boy who was treated with ceftriaxone several days for acute tonsillitis, complicated with toxic epidermal necrolysis (TEN) that was initially diagnosed as drug eruption. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a thirdgeneration cephalosporin, a frequent choice in the treatment of childhood infections. To the best of our knowledge, this is the first case of ceftriaxone-induced toxic epidermal necrolysis in genital area in the English literature
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Abstract (Original Language): 
Akut tonsillit nedeniyle seftriakson ile tedavi edilen ve ilaç erupsiyonu sonrası toksik epidermal nekrolizis (TEN) gelişen bir olguyu sunduk. Uzun yarılanma ömrü, geniş spektrumu, yüksek doku penetrasyon hızı, güvenilirliliği bir üçüncü kuşak sefalosporin olan seftriaksonu çocukluk çağı enfeksiyonlarında tercih edilen bir ajan yapmıştır. Bilgimiz dahilinde bu vaka İngilizce literatür genital bölgede seftriaksona ikincil TEN gelişen ilk vakadır.
FULL TEXT (PDF): 
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  • 2
29-31
  • English

REFERENCES

References: 

1. Avakian R, Flowers FP, Araujo OE, Ramos-Caro FA. Toxic epidermal necrolysis: a review. J Am Acad Dermatol 25:69-79, 1991.
2. Chave TA, Mortimer NJ, Sladden MJ, Hall AP, Hutchinson PE. Toxic epidermal necrolysis: current evidence, practical management and future directions. Br J Dermatol 153:241-53, 2005.
3. Cohen S, Billiq A, Ad-El D. Ceftriaxone-induced toxic epidermal necrolysis mimicking burn injury: a case report. J Med Case Reports 3: 9323, 2009.
30
İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 75 • Sayı / Number:2 • Yıl/Year: 2012
8. Roujeau JC, Kelly JP, Naldi L, Rzany B, Sterns RS, Anderson T,
9. Auquier A, Bastuji-Garin S, Correia O,
7. Lam A, Randhawa I, Klaustermeyer W. Cephalosporin induced toxic epidermal necrolysis and subsequent penicillin drug exanthem. Allergol Int 57: 281-284,2008.
8. Paul C, Wolkenstein P, Adle H, Wechsler J, Garchon HJ, Revuz J, Roujeau JC. Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. Br J Dermatol 134:710-714, 1996.
9. Roujeau JC, Kelly JP, Naldi L, Rzany B, Sterns RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F,et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333: 1600-7, 1995.
1. 909, 2005.
ve kan gazları normaldi. Abdominal ultrasonografide renal meduller piramislerde saptanan hiperekojenitede azalma saptandı.
Tablo 1. Olgunun serum laboratuvar bulguları
Kan
Yatış 3. ay
Üre (mg/dL)
22
9
Kreatinin (mg/dL)
0,57
0,36
Albumin (g/dL)
3,6
3,4
Glukoz (mg/dL)
92
89
Na (mEq/L)
139
133
K (mEq/L)
1,4
3,6
Cl (mEq/L)
116
103
Ca (mg/dL)
14,4
8,6
P (mg/dL)
4,2
3,5
ALP (IU/L)
294
273
Mg (mEq/L)
1,5
0.9
Ürik asit (mg/dL)
4,3
2.9
pH
7,16
7,39
HCO3 (mmol/L)
9,9
19,8
İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 75• Sayı / Number: 2 • Yıl/Year: 2012
31
4. Ceftriaxone. In: Taketomo CK, Hodding JH, Kraus MD, editors. Lexi-Comp’s pediatric dosage handbook, 10th Edition. USA,2003: 240-242.
5. Ducic I, Shalom A, Rising W, Nagamoto K, Munster AM. Outcome of patients with toxic epidermal necrolysis syndrome revisited. Plast Reconstr Surg 110:768-773,2002.
6. Harr T, French LE. Toxic epidermal necrolysis and Stevens-Johnson syndrome. Orphanet J Rare Dis 5: 39, 2010.
7. Lam A, Randhawa I, Klaustermeyer W. Cephalosporin induced toxic epidermal necrolysis and subsequent penicillin drug exanthem. Allergol Int 57: 281-284,2008.
8. Paul C, Wolkenstein P, Adle H, Wechsler J, Garchon HJ, Revuz J, Roujeau JC. Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. Br J Dermatol 134:710-714, 1996.
9. Roujeau JC, Kelly JP, Naldi L, Rzany B, Sterns RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F,et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333: 1600-7, 1995.

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