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ÜÇ OLGU İLE METANOL ZEHİRLENMESİ: ACİL SERVİSTE TANI VE TEDAVİ

METHANOL POISONING IN THREE CASES: DIAGNOSIS AND TREATMENT IN EMERGENCY DEPARTMENT

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Methanol is a very poisonous substance that is used as an industrial solvent and automotive antifreeze. Toxic dose is between 20-250 ml and causes neurological symptoms such as headache, cerebral edema and putamen necrosis within the first 12 to 14 hours. Central nervous system and visual cortex are the main areas which are damaged by methanol poisoning. Methyl alcohol is not toxic until its toxic metabolites turn into formic acid. Formic acid is especially responsible for the clinical findings. Serum half-life of methanol is 14 to 20 hours in mild and 24 to 30 hours in severe toxicity. Gastric lavage, fomepizole, ethanol and hemodialysis are used in the treatment. In this study, we aimed to review and discuss information from literature about the treatment and monitoring of methanol poisoning in three cases followed at emergency department.
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Abstract (Original Language): 
Metanol endüstriyel bir çözücü ve otomotiv antifrizi olarak kullanılan çok zehirli bir maddedir. Toksik doz 20-250 ml. arasında olup 12-14 saat içinde baş ağrısı, beyin ödemi ve putamen nekrozu gibi nörolojik bulgular verir. Merkezi sinir sistemi ve görme yolu metanol zehirlenmesinde etkilenen ana bölgelerdir. Metil alkol toksik metabolitleri olan formaldehit ve formik aside dönüşünceye kadar toksik değildir. Klinik bulgulardan özellikle formik asit sorumludur. Metanolün hafif toksititeden sonra serum yarılanma ömrü 14-20 saat, şiddetli toksisiteden sonra 24-30 saattir. Tedavide gastrik lavaj, fomepizol, etanol ve hemodializ kullanılır. Bu çalışmada üç olgu ile acil serviste takip edilen metanol zehirlenmesinin takip ve tedavisinin gözden geçirilmesi amaçlanmıştır
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  • 2
25-27
  • English

REFERENCES

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